In our previous study, the demand-only PCEA method was associated with a 35% breakthrough pain
rate, which compares with 10% associated with PCEABI in this study.
Even though the incidence of breakthrough pain
is high in cancer patients, it is often not correctly identified nor reported," said Nash Gabrail, MD, MRCP, of the Gabrail Cancer Center and clinical investigator for Lazanda.
We measured analgesic efficacy by the incidence of breakthrough pain
in parturients necessitating epidural bolus top-ups by an attending anaesthetist.
The patients were surveyed by quetionnaire and asked whether they preferred the fentanyl buccal tablet or their previous breakthrough pain
medicine, and 158 patients (80%) said they preferred fentanyl buccal tablets.
82% of cancer patients said breakthrough pain
had a negative effect on their emotional health.
Lazanda, which uses our patented PecSys drug delivery system, is designed to deliver medicine in a rapid, but controlled manner, and provides patients with an effective alternative to manage their breakthrough pain
is defined as one or several daily, often intermittent flares ("breakthroughs") of pain that can occur even though a person is taking medications for regular pain control.
We looked at about 500 breakthrough pain
episodes and about half were relieved at 30 minutes, if you consider 'greater than 33%' to be relief," Dr.
under the trade name Actiq) at home for breakthrough pain
and avoid trips to the emergency room.
The product offers patients and clinicians a simple, patient friendly and predictable way of delivering fentanyl transmucosally while retaining the individualized dose titration aspects required for optimal treatment of breakthrough pain
The survey, which is the first international survey to look in detail at breakthrough cancer pain (BTCP) from a patient perspective, show that up to 45% of cancer patients experiencing breakthrough pain
do not adhere to medication despite suffering from devastating episodes.
The product Rapinyl, developed for rapid relief of cancer breakthrough pain
, is based on the technology for fast dissolving sublingual tablets.