breakthrough dose

breakthrough dose

an as-needed dose of medication for sporadic worsening of pain; given to palliate breakthrough pain.

break·through dose

(brākthrū dōs)
As needed dosage of medication for sporadic worsening of pain; given to palliate breakthrough pain.
References in periodicals archive ?
The breakthrough dose is generally 10%-20% of the total 24-hour oral dose of the sustained-acting opioid.
Patients on long-acting morphine may still experience breakthrough pain and breakthrough doses of short-acting morphine (1/6 of the total MST Continus dose) should be prescribed.
NB: Continue to give breakthrough doses of short-acting morphine (10 mg) Example 2.