brain metastases

brain metastases

A generic term for cancer which has spread from a primary tumour, most commonly small cell carcinoma, of the lung to the brain.

brain metastases

Oncology Cancer that has spread from a primary tumor, most commonly, small cell carcinoma of the lung, to the brain
References in periodicals archive ?
Tucatinib is currently being evaluated in a randomized global pivotal trial called HER2CLIMB for patients with HER2-positiv metastatic breast cancer, including patients with or without brain metastases.
Novocure has ongoing or completed clinical trials investigating TTFields in brain metastases, non-small cell lung cancer, pancreatic cancer, ovarian cancer and mesothelioma.
For example, 50% of the patients in the melanoma rescue cohort had liver metastases, 77% had other visceral metastases, and 18% had brain metastases.
Recursive partitioning analysis (RPA) of prognostic factors in three radiation therapy oncology group (RTOG) brain metastases trials.
Pfizer Inc today announced full results from the Phase 2 clinical trial of the investigational, next-generation tyrosine kinase inhibitor lorlatinib that exhibited clinically meaningful activity against lung tumors and brain metastases in a range of patients with ALK-positive and ROS1-positive advanced non-small cell lung cancer (NSCLC), including those who were heavily pretreated.
Although surgical intervention may be recommended for one of various reasons in the management of these tumours, including but not limited to conformation of diagnosis, relief of mass effect, improvement of neurological status and prolongation of survival, the guidelines for management of brain metastases remain largely subjective and therefore controversial.
The goal of the study was to find novel, tumor-specific therapies that could target multiple brain metastases without damaging nearby tissues.
The overall intracranial response rate (OIRR) in patients with measurable brain metastases was found to be 57% for patients treated with Zykadia, while this figure stood at 22% for those treated with chemotherapy.
Chinese researchers demonstrate that icotinib creates better progression-free survival with fewer side effects than whole brain radiation in non-small cell lung cancer patients with brain metastases.
Patients with brain metastases had an even better response rate, 72.
A bone scan and additional brain imaging are, therefore, not routinely indicated unless the patient has specific symptoms or signs to suggest bone or brain metastases.