brain metastases

A generic term for cancer which has spread from a primary tumour, most commonly small cell carcinoma, of the lung to the brain.

brain metastases

Oncology Cancer that has spread from a primary tumor, most commonly, small cell carcinoma of the lung, to the brain

References in periodicals archive ?

Tucatinib is currently being evaluated in a randomized global pivotal trial called HER2CLIMB for patients with HER2-positiv metastatic breast cancer, including patients with or without brain metastases.

Seattle Genetics completes Cascadian acquisition, getsTucatinib rights

Novocure has ongoing or completed clinical trials investigating TTFields in brain metastases, non-small cell lung cancer, pancreatic cancer, ovarian cancer and mesothelioma.

Oncology Firm Novocure Closes USD 150m Term Loan

For example, 50% of the patients in the melanoma rescue cohort had liver metastases, 77% had other visceral metastases, and 18% had brain metastases.

Novel agent shows potential benefits for refractory disease

Recursive partitioning analysis (RPA) of prognostic factors in three radiation therapy oncology group (RTOG) brain metastases trials.

Systemic Therapy after Radiotherapy Significantly Reduces the Risk of Mortality of Patients with 1-3 Brain Metastases: A Retrospective Study of 250 Patients

Pfizer Inc today announced full results from the Phase 2 clinical trial of the investigational, next-generation tyrosine kinase inhibitor lorlatinib that exhibited clinically meaningful activity against lung tumors and brain metastases in a range of patients with ALK-positive and ROS1-positive advanced non-small cell lung cancer (NSCLC), including those who were heavily pretreated.

United States : Pfizer Presents Full Results from Phase 2 Study of Next-Generation Investigational ALK-Inhibitor Lorlatinib in ALK-Positive and ROS1-Positive Advanced Non-Small Cell Lung Cancer

Although surgical intervention may be recommended for one of various reasons in the management of these tumours, including but not limited to conformation of diagnosis, relief of mass effect, improvement of neurological status and prolongation of survival, the guidelines for management of brain metastases remain largely subjective and therefore controversial.

Role of surgery in brain metastases

The goal of the study was to find novel, tumor-specific therapies that could target multiple brain metastases without damaging nearby tissues.

Stem cell-based therapy may target skin-to-bram cancer

The overall intracranial response rate (OIRR) in patients with measurable brain metastases was found to be 57% for patients treated with Zykadia, while this figure stood at 22% for those treated with chemotherapy.

FDA approves expanded use of Novartis drug Zykadia in first-line ALK-positive metastatic NSCLC

Chinese researchers demonstrate that icotinib creates better progression-free survival with fewer side effects than whole brain radiation in non-small cell lung cancer patients with brain metastases.

Summary of Research Presentations From the IASLC 17th World Conference on Lung Cancer Tuesday, December 6, 2016

Patients with brain metastases had an even better response rate, 72.

Novartis Drug Zykadia Beats Chemotherapy In Lung Cancer Patients

Stereotactic radiosurgery for the management of brain metastases.

Radiocirugia de lesion metastasica en la fosa posterior con infiltracion leptomeningea focal: reporte de caso y revision de la literatura

A bone scan and additional brain imaging are, therefore, not routinely indicated unless the patient has specific symptoms or signs to suggest bone or brain metastases.