bradyzoite


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bra·dy·zo·ite

(brad'ē-zō'īt),
A slowly multiplying encysted form of sporozoan parasite typical of chronic infection with Toxoplasma gondii. It has also been called a merozoite or zoite; the complex of bradyzoites within an enclosing membrane has also been called a pseudocyst, though it is now regarded as a true cyst.
[brady- + G. zōē, life]
Farlex Partner Medical Dictionary © Farlex 2012

bra·dy·zo·ite

(brad'ē-zō'īt)
Toxoplasma gondii life-cycle stage that forms within a cystlike structure. The organisms multiply slowly but may be transformed into tachyzoites when the host's immune system is impaired.
[brady- + G. zōē, life]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
GRA7 and ROP2 could express in two important stages of Toxoplasma life cycle, tachyzoite and bradyzoite.
In addition, recombinant SAG1 and BAG1 antigens were used since these are typical antigens characterising the tachyzoite and bradyzoite stage of T.
gondii is found in three morphologically different strains which are named as tachyzoite, bradyzoite, and sporozoite.
Stage conversion between tachyzoite and bradyzoite forms of Toxoplasma is associated with morphological and molecular biological changes, including stage-specific antigen expression and alterations to metabolism [8].
Scientists working in various fields, including microbiology, in Europe, the US, Japan, and Brazil contribute 26 chapters on its history and life cycle, the molecular epidemiology and population structure, human infection, ocular disease, toxoplasmosis in wild and domestic animals, animal models and therapeutics, biochemistry and metabolism, calcium storage and homeostasis, the role of secretory proteins, the parasite's structures, host immune responses, nucleotide and amino acid metabolism in comparison to other Apicomplexa, bradyzoite development, chemical biology, cerebral toxoplasmosis, innate and adaptive immunity, and vaccination.
They travel in blood and reach different body parts and transformed into bradyzoite cysts (5-10 um diameter) present in skeletal muscles and neural tissues.
In an effort to evade host defenses, tachyzoites switch to a slower growing bradyzoite where they are able to lay dormant.
Atovaquone, a structural analog of protozoan ubiquinone, has been shown to have significant activity against the bradyzoite stage of Toxoplasma in both in vitro and in vivo assays [9-12].
The organism exits in nature in many forms: macro- and microgametes, the oocyte (which releases sporozoites), the tissue cyst, which contains and may release bradyzoite, and tachyzoite.
gondii infection, bradyzoite containing cysts were counted in HE sections of liver, lung, and brain (Table 3).