bradykinin


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bradykinin

 [brad″e-ki´nin]
a nonapeptide kinin formed from a plasma protein, high-molecular-weight (HMW) kininogen by the action of kallikrein; it is a very powerful vasodilator that increases capillary permeability and, in addition, constricts smooth muscle and stimulates pain receptors.

bra·dy·ki·nin

(brad'ē-kī'nin),
The nonapeptide Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, produced from the decapeptide kallidin (bradykininogen) that is produced from α2-globulin by kallikrein, normally present in blood in an inactive form and similar to trypsin in action; bradykinin is one of several plasma kinins, is a potent vasodilator, and is one of the physiologic mediators of anaphylaxis released from cytotropic antibody-coated mast cells following reaction with antigen (allergen) specific for the antibody.
[brady- + G. kineō, to move]

bradykinin

(brăd′ĭ-kī′nĭn, -kĭn′ĭn)
n.
A biologically active polypeptide, consisting of nine amino acids, that forms from a blood plasma globulin and mediates the inflammatory response, increases vasodilation, and causes contraction of smooth muscle.

bradykinin

A vasoactive nonapeptide (RPPGFSPFR) formed by action of proteases on kininogens, which is very similar to kallidin (the same sequence, but with an additional N terminal lysine). It is a potent vasodilator, increasing the permeability of postcapillary venules and acting on endothelial cells to activate phospholipase A2; it is also spasmogenic for some smooth muscle and evokes pain.

bra·dy·ki·nin

(brad'ē-kī'nin)
The nonapeptide Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, normally present in blood in an inactive form; one of the plasma kinins, a potent vasodilator and mediator of anaphylaxis.
[brady- + G. kineō, to move]

bradykinin

A peptide that widens blood vessels (vasodilatation) and lowers blood pressure, increases capillary permeability and the secretion of saliva and mediates pain associated with inflammation. Bradykinin is inactivated by the angiotensin-converting enzyme.

bradykinin

a hormone formed from a kininogen in the blood plasma that has the effect of rapid VASODILATION in the skin.

bra·dy·ki·nin

(brad'ē-kī'nin)
One of several plasma kinins, a potent vasodilator; physiologic mediator of anaphylaxis released from cytotropic antibody-coated mast cells following reaction with antigen (allergen) specific for the antibody.
[brady- + G. kineō, to move]
References in periodicals archive ?
Role of bradykinin in inflammatory arthritis: identification and functional analysis of bradykinin receptors on human synovial fibroblasts.
As stated previously, cerebral ischemia increases the amount of B2 bradykinin receptors in the brain which can increase the risk of developing angioedema with tPA, but it is unclear if this increase in receptors occurs only in ischemic CVAs or in transient ischemic accidents (TIAs) as well.
The negative peptide bradykinin, Caeridin-1, and S5-Caeridin-1 barely showed membrane-permeabilising activity up to 512 [micro]M.
Queme et al., "Bradykinin and nerve growth factor play pivotal roles in muscular mechanical hyperalgesia after exercise (delayed-onset muscle soreness)," Journal of Neuroscience, vol.
Pesquero et al., "Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema," Stroke, vol.
ADIPOQ = adiponectin, C1Q and collagen domain containing; IRS2 = insulin receptor substrate 2; ACSL1 = acyl-CoA synthetase long chain family member 1; PLIN = lipid storage droplet 2-like; CD36 = CD36 molecule; PNPLA3 = patatin-like phospholipase domain containing 3; SCD = stearoyl-CoA desaturase; BDKRB2 = bradykinin receptor B2; ADORA3 = adenosine A3 receptor; SOX9 = sex determining region Y-box 9; TXN = thioredoxin; CDKN2C = cyclin-dependent kinase inhibitor 2C; GSTM3 = glutathione S-transferase mu 3; PTH1R = parathyroid hormone 1 receptor; CKB = creatine kinase B; AOC1 = amine oxidase, copper containing 1; AOC3 = amine oxidase, copper containing 3; TIMP1 = TIMP metallopeptidase inhibitor 1; PTN = pleiotrophin.
Treatment with bradykinin reduced TF development in [Il17ra.sup.-/-] mice via upregulating Mmp2 and tPA levels in the obstructed kidney.
While functional anti-FceRIa or anti-lgE can cause histamine release and risk of anaphylaxis, C1 INH deficiency or dysfunction and increased bradykinin can lead to risk of laryngeal angioedema, and things as simple as a tooth extraction can be life-threatening, as well as the endotracheal intubation meant to save a life, "Trauma, including surgically induced trauma, especially involving endotracheal intubation or manipulation, may trigger life-threatening laryngeal edema." (21,47,48)
serpens are alkaloids, saponins, tannins and flavonoids which may be responsible for inhibiting the mediators release like prostaglandins, histamine, serotonin or bradykinin as pain suppressors in the late phase [24, 36] The outcome of the study is that the anti-nociceptive property of the plant was mediated through the peripheral mechanism; augmented by interference of centrally acting pain mediators.
So far, only ACE, alpha-actibnin 3 (ACTN3) and bradykinin receptor B2 (BRDKB2) (due to connections with ACE) [27, 28], are genes most frequently connected with enhanced performance.
Bradykinin (BK) is a low molecular weight nonapeptide that exerts powerful effects on different pathophysiological conditions.
However, it mainly suffers from injection pain,12 as an inevitable issue of which even adults are afraid.13 With elusive mechanisms, the injection pain of propofol has mainly been attributed to the pain-inducing effect originating from the contact between aqueous phase of emulsion and free nerve endings14 or the delaying effect based on bradykinin produced by the activated kinin cascade system.15 Bradykinin leads to local phlebectasia and increases vascular wall permeability, so propofol can penetrate the vascular wall to contact with more free nerve endings, thus aggravating the injection pain.16