T gene

(redirected from brachyury protein)

T gene

A genes on chromosome 6q27 that encodes brachyury, an embryonic nuclear transcription factor that effects transcription of genes required for mesoderm formation and differentiation, and mediates epithelial-mesenchymal transition. It is localised to notochord-derived cells.

Molecular pathology
Brachyury is the definitive diagnostic marker of chordoma; it is overexpressed in various cancers and promotes invasion.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Herrmann, "Immunohistochemical analysis of the Brachyury protein in wild-type and mutant mouse embryos," Developmental Biology, vol.