Summary of 58 Nonchordomatous Tumors Also Evaluated for Brachyury Expression Case Age, No.
Lately, gene expression analysis has unraveled a key nuclear transcription factor, brachyury or T as a specific marker for chordoma.
Brachyury staining was performed in all 51 chordomas (Table 1).
Wesley Hsu, MD, Wake Forest University Health Sciences Inhibition of FGFR1/MAPK signaling to downregulate brachyury
for the treatment of lung cancer
A prominent example of this coordination is found in the gastrulation of amniotes, where Brachyury
(Bra), a transcription factor, is synchronously and transiently expressed in a localized population, the Primitive Streak (PS).
Spermatogonial stem cell self-renewal requires ETV5-mediated downstream activation of Brachyury
Upcoming research will focus on understanding why the alteration in brachyury is so critical for chordoma development and what other factors are at play.
The research team is currently poised to launch the next phase of the Chordoma Genome Project, which will attempt to determine what actually triggers the development of chordoma once the brachyury variation creates the predisposition.
42-44) Recently, inhibin A, D240, and brachyury have been found to be present in hemangioblastomas and may be helpful in differentiating them from other CCTs.
Expression of brachyury in hemangioblastoma: potential use in differential diagnosis [published online ahead of print March 25, 2012].
molecular basis for the structural asymmetry of the body has been linked to a complex interaction of fibroblast growth factor 8, Nodal gene, Lefty 2 gene, PITX2 gene, Lefty 1 gene, Sonic HedgeHog (SHH) gene, Brachyury
(T) gene and expression of Snail transcription factor .
, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis.