brachyury


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brachyury

An embryonic nuclear transcription factor encoded by T gene within the T-box complex of genes on chromosome 6q27, which binds to the palindromic T site on DNA. Brachyury effects transcription of genes required for mesoderm formation and differentiation, mediates epithelial-mesenchymal transition and is localised to notochord-derived cells.

Molecular pathology
Brachyury is the definitive diagnostic marker of chordoma, a malignancy arising from remnant notochordal cells in the vertebrae; germline duplication of brachyury confers susceptibility to chordoma. It is overexpressed in various cancers and promotes invasion.

brachyury

shortness of the tail, as in some Manx cats.
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M2 EQUITYBITES-January 19, 2018-Bavarian Nordic initiates clinical trial with Brachyury in cancer metastasis
NORDIC BUSINESS REPORT-January 19, 2018-Bavarian Nordic initiates clinical trial with Brachyury in cancer metastasis
M2 PHARMA-January 19, 2018-Bavarian Nordic initiates clinical trial with Brachyury in cancer metastasis
The tumor cells are typically immunoreactive for cytokeratins, EMA, S100 protein, and Brachyury, with the latter being highly specific (Figure 12, A through D).
Amongst these, analyses of SRY (Sex Determining Region Y)-box 1 (Sox1), paired box 6 (Pax6), neural cell adhesion molecule (NCAM) and neuroectodermal stem cell marker (Nestin) might be suitable to characterize ectodermal commitment; [alpha]-fetoprotein, cytokeratins, somatostatin, bone morphogenetic protein 4 (BMP4), GATA binding protein 4 (GATA4) and hepatocyte nuclear factor-4 are commonly expressed in the endoderm; brachyury, a-cardiac actin, and the atrial natriuretic factor are expressed at the mesoderm level, as reviewed by Pistollato et al.
We herein report an exceptional case of extra-axial dedifferentiated chordoma confirmed by the expression of brachyury, the first case report of this kind," reported surgical pathologist Dr.
For real-time quantitative PCR, the following predeveloped TaqMan[R] assays were purchased from Applied Biosystems (Thermo Fisher Scientific; Waltham, MA, USA): octamer-binding transcription factor 4 (OCT4) and the divergent homeodomain protein NANOG as undifferentiated stem cell markers [20-22], BRACHYURY as mesoderm marker [23], the homeobox protein NKX2.
A prominent example of this coordination is found in the gastrulation of amniotes, where Brachyury (Bra), a transcription factor, is synchronously and transiently expressed in a localized population, the Primitive Streak (PS).
This Fgf9/16/20 signal eventually induces Brachyury expression only in the presumptive notochord cells.
3) This is confirmed by the recent evidence that brachyury, a transcription factor involved in notochordal development, is detectable in the disease.
La evidencia reciente ha mostrado resultados prometedores con el uso de Imatinib, un inhibidor de la tirosin cinasa, ademas, otras investigaciones han conducido a la identificacion de varios marcadores tumorales, se encontro una importante asociacion entre la proteina brachyury y la proliferacion del tumor, esta proteina es expresada hasta en 90% de los cordomas, el mecanismo de accion no ha sido descrito, pero parece estar implicada en la patogenesis del tumor.
They emphasize the need for elucidating the regulatory factors operating between expression of the brachyury gene and regulation of the polymerization and positioning of actin responsible for gastrulation invagination, notochord movements, and neural tube closure.