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(1) Comfrey, see there; Symphytum officinal.
(2) Eupatorium perfoliatum, agueweed, crosswort, feverwort, Indian sage, thoroughwort. A perennial herb which contains pyrrolizidine alkaloids, flavonoids (e.g., eupatorin, quer-cetin, rutin), terpenoids, volatile oil (tremerol and resin; it is antipyretic and diaphoretic, and has been used for arthritis, colds, diarrhoea, malaria, respiratory congestion, rheumatic complaints, snakebites, as a digestive tonic and was regarded by some herbalists as a cure-all. Boneset owes its name to its efficacy in treating breakbone fever.
Diarrhoea, nausea, vomiting; fresh boneset contains the toxin tremerol, which causes vomiting, shortness of breath and, if in excess, coma and death; boneset is hepatotoxic due to pyrrolizidine alkaloids.