(2006) Biomechanical and molecular regulation of
bone remodeling. Annual Review of Biomedical Engineering 8, 455-498.
This study aims to prepare phytochemical incorporated nano-calcium silicate implants and evaluate
bone remodeling around the implants over longer periods of time.
In the course of
bone remodeling, bone resorption is closely associated with new bone formation.
The balance between osteoclasts and osteoblasts which determines the rate of
bone remodeling could be disturbed by several molecular pathways.
Although the mechanism still needed further research, n-3 PUFAs has been shown to reduce the formation of PGE-2 and promotes bone formation through enhancing the expression of insulin-like growth factors, which are powerful growth stimulators for
bone remodeling [29, 30].
In the following sections, the algorithm of the
bone remodeling and the corresponding 3D finite element model will be described.
Gap junctions formed by connexins (Cx) play an important role in transmitting signals between bone cells, which are responsible for bone formation and
bone remodeling. Gap junctional intercellular communication (GJIC) has been demonstrated to mediate the process of osteoblast differentiation and bone formation (10).
Key Words: Diabetes Mellitus, Orthodontic Tooth Movement, Osteoclast,
Bone Remodeling.
Paget's disease of bone is a localized
bone remodeling disorder of uncertain etiology, (10) although environmental and genetic factors are thought to be involved.
Thus, repeated microinjuries to the subchondral bone might trigger the
bone remodeling process, activating the osteoclasts, breaking down various osteolysis enzymes, and promoting localized osteolysis, subsequently causing destruction of the trabecular bone.
Analogy of strain energy density based
bone remodeling algorithm and structural topology optimization, J Biomech Eng 131.
Prolonged bisphosphonate therapy may contribute to atypical subtrochanteric fractures by over suppressing
bone remodeling leading to alterations in bone mineral and organic matrix.3 As a consequence of the reduction in bone turnover by bisphosphonates, the mineralization of bone is significantly altered.
