bone morphogenetic protein-10

bone morphogenetic protein-10

A protein encoded by BMP10 on chromosome 2p13.3, which belongs to the TGF-beta family of growth factors and plays a key role in trabeculation of the embryonic heart, acting via receptor serine/ threonine kinases.
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The Neuregulin 1-ErbB 2/4, EphrinB 2/EphrinB 4, and bone morphogenetic protein-10 signaling pathways are required for ventricular trabecular formation.
AVC: atrioventricular canal; BMP2: bone morphogenetic protein-2; Tbx2: T-box 2; EMT: epithelial-to-mesenchymal transition; MMP-2: matrix metalloproteinase-2; VEGFR 2: vascular endothelial growth factor receptor 2; VEGF: vascular endothelial growth factor; BMP-10: bone morphogenetic protein-10; OFT: outflow tract.
Expression of bone morphogenetic protein-10 mRNA during chicken heart development.

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