bone metastases

bone metastases

Cancer that has spread from a primary tumour to the bone marrow; in descending order of frequency, bone mets originate from: breast, prostate, lung, colon, stomach, bladder, uterus, rectum, thyroid, kidney.

Clinical findings
Bone pain, soft-tissue swelling or a pathologic fracture after minor or no reportable trauma. Chronic and severe pain, spinal epidural compression leading to spinal cord compression and bone marrow failure are complications of bone metastases that can drastically reduce the patient's quality of life and life expectancy.
 
DiffDx
• Osteolytic metastases—Osteoarthritis (subchondral cysts, Schmorl nodes), metabolic bone disease, cystic angiomatosis and infiltrative bone marrow lesions.
• Sclerotic metastases—Bone islands, tuberous sclerosis, mastocytosis or osteopoikilosis.

bone metastases

Oncology Cancer that has spread from a primary tumor to the bone
References in periodicals archive ?
With progression of the disease, bone metastases alter the integrity of the skeletal system leading to pathological bone fractures and bone pain, which affects the quality of life of the patient.
During the same period, we worked with clinical collaborators at Duke Cancer Institute to plan our next trial for GMI-1359, a dual antagonist of E-selectin and CXCR-4, and defined individuals with breast cancer and bone metastases as our initial target study population," said CEO Rachel King.
The incidence of bone metastases varies significantly depending on the primary site, with breast and prostate cancer accounting for up to 70% of patients with metastatic disease [1].
More than 70% of patients with solid tumors develop painful bone metastases during the course of their disease in the spine, pelvis, and extremities1.
Bone metastases in HCC are uncommon with an incidence of 3% to 20%.1 Screening for bone metastasis is not a routine practice.
Around 2 in 3 patients with late-stage breast and prostate cancer, and 1 in 3 with late-stage lung, thyroid, and kidney cancer will develop bone metastases. This can cause debilitating pain, which has a significant impact on patients' quality of life.
Sr89 works by delivering radiation local to the bone metastases that results in pain relief by selectively targeting and accumulating in metastatic bone lesions with minimal risk of toxicity to surrounding normal tissue, concluded the company.
After lung and liver, osseous metastases, particularly osteolytic bone metastases, are among the most common types of metastases to occur in advanced cancer, and the majority of the affected patients suffer from severe pain refractory to common treatment methods (2, 37).
14, 2018 (HealthDay News) -- A model with four categories has been developed to stratify patients with symptomatic long bone metastases (LBM) based on their expected survival, according to an article published online Feb.
Lytic bone metastases are due to a variety of primary tumors and are more common than sclerotic metastases [5].
Amgen's sBLA for XGEVA (denosumab) to expand the currently approved indication for the prevention of skeletal-related events in patients with bone metastases from solid tumors, has been approved to include multiple myeloma.
Bone metastases of breast cancer are frequently found in the rib, sternum, vertebrae, or pelvis and are refractory to radiation therapy combined with standardized HER2-binding monoclonal antibody and/or endocrine treatments and, if necessary, cytotoxic chemotherapy comprising a widespread regimen such as cyclophosphamide, epirubicin, and 5-fluorouracil (CEF) [1].