bone metastases

Cancer that has spread from a primary tumour to the bone marrow; in descending order of frequency, bone mets originate from: breast, prostate, lung, colon, stomach, bladder, uterus, rectum, thyroid, kidney.

Clinical findings
Bone pain, soft-tissue swelling or a pathologic fracture after minor or no reportable trauma. Chronic and severe pain, spinal epidural compression leading to spinal cord compression and bone marrow failure are complications of bone metastases that can drastically reduce the patient's quality of life and life expectancy.

DiffDx
• Osteolytic metastases—Osteoarthritis (subchondral cysts, Schmorl nodes), metabolic bone disease, cystic angiomatosis and infiltrative bone marrow lesions.
• Sclerotic metastases—Bone islands, tuberous sclerosis, mastocytosis or osteopoikilosis.

bone metastases

Oncology Cancer that has spread from a primary tumor to the bone

References in periodicals archive ?

With progression of the disease, bone metastases alter the integrity of the skeletal system leading to pathological bone fractures and bone pain, which affects the quality of life of the patient.

Can Neutrophil/Lymphocyte and Platelet/Lymphocyte Rates Predict Bone Metastasis in Prostate Cancer Patients?/Notrofil/Lenfosit ve Trombosit/Lenfosit Oranlari Prostat Kanseri Olgularinda Kemik Metastazini Ongorebilir mi?

During the same period, we worked with clinical collaborators at Duke Cancer Institute to plan our next trial for GMI-1359, a dual antagonist of E-selectin and CXCR-4, and defined individuals with breast cancer and bone metastases as our initial target study population," said CEO Rachel King.

GlycoMimetics reports Q1 EPS (33c), consensus (34c)

The incidence of bone metastases varies significantly depending on the primary site, with breast and prostate cancer accounting for up to 70% of patients with metastatic disease [1].

A RETROSPECTIVE STUDY OF TH.E IMPACT OF RADIATION FRACTIONATION ON PAINFUL BONE METASTASIS

More than 70% of patients with solid tumors develop painful bone metastases during the course of their disease in the spine, pelvis, and extremities1.

STUDY OF EFFICACY OF HYPOFRACTIONATED RADIOTHERAPY 8 GRAY IN SINGLE FRACTION IN PALLIATION OF PAIN SECONDARY TO BONE METASTASIS

Bone metastases in HCC are uncommon with an incidence of 3% to 20%.1 Screening for bone metastasis is not a routine practice.

A rare presentation of osseous metastasis in Hepatocellular Carcinoma (HCC) on bone scintigraphy

Sr89 works by delivering radiation local to the bone metastases that results in pain relief by selectively targeting and accumulating in metastatic bone lesions with minimal risk of toxicity to surrounding normal tissue, concluded the company.

Q BioMed Inc reports US FDA filing for new facility to manufacture Strontium Chloride Sr89 Injection USP for metastatic cancer bone pain

After lung and liver, osseous metastases, particularly osteolytic bone metastases, are among the most common types of metastases to occur in advanced cancer, and the majority of the affected patients suffer from severe pain refractory to common treatment methods (2, 37).

CT fluoroscopy-guided percutaneous osteoplasty with or without radiofrequency ablation in the treatment of painful extraspinal and spinal bone metastases: technical outcome and complications in 29 patients

14, 2018 (HealthDay News) -- A model with four categories has been developed to stratify patients with symptomatic long bone metastases (LBM) based on their expected survival, according to an article published online Feb.

New Model Stratifies Patients With Long Bone Metastases; Model includes four prognostic categories with clinical consequences to predict median survival

Lytic bone metastases are due to a variety of primary tumors and are more common than sclerotic metastases [5].

Sclerotic Bone Metastasis in Pulmonary Adenocarcinoma

Amgen's sBLA for XGEVA (denosumab) to expand the currently approved indication for the prevention of skeletal-related events in patients with bone metastases from solid tumors, has been approved to include multiple myeloma.

Bone metastases of breast cancer are frequently found in the rib, sternum, vertebrae, or pelvis and are refractory to radiation therapy combined with standardized HER2-binding monoclonal antibody and/or endocrine treatments and, if necessary, cytotoxic chemotherapy comprising a widespread regimen such as cyclophosphamide, epirubicin, and 5-fluorouracil (CEF) [1].

Rate of Clinical Complete Response for 1 Year or More in Bone-Metastatic Breast Cancer after Comprehensive Treatments including Autologous Formalin-Fixed Tumor Vaccine