bone marrow suppression


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suppression

 [sŭ-presh´un]
the act of holding back or checking.
1. the stopping or inhibition of something, such as a secretion, excretion, normal discharge, or other function.
2. in psychiatry, conscious inhibition of an unacceptable impulse or idea as contrasted with repression, which is unconscious.
3. in genetics, a second mutation occurring at a site different from the first mutation site and able to mask or suppress the phenotypic expression of the first mutation; the organism appears to be reverted but is in fact doubly mutant.
4. inhibition of the erythrocytic stage of Plasmodium to prevent clinical attacks of malaria; used for prophylaxis.
5. cortical inhibition of perception of objects in all or part of the visual field of one eye during binocular vision.
bone marrow suppression reduction of the cell-forming functions of bone marrow, such as by a drug or because of replacement of the marrow by a disease process. Called also myelophthisis and myelosuppression.
labor suppression in the nursing interventions classification, a nursing intervention defined as controlling uterine contractions prior to 37 weeks of gestation to prevent preterm birth. See also labor.
lactation suppression in the nursing interventions classification, a nursing intervention defined as facilitating the cessation of lactation and minimizing breast engorgement after childbirth.
overdrive suppression the suppression of intrinsic cellular automaticity by a rapid outside stimulus. In cardiology this refers to the inhibitory effect of a faster pacemaker on a slower pacemaker. The faster rate causes an accumulation of intracellular sodium, stimulating the sodium-potassium pump, which hyperpolarizes the cell so that it takes longer to reach threshold potential. This phenomenon is present in healthy His-Purkinje cells but decreases with a decrease in membrane potential and loss of fast sodium channels.

bone marrow suppression

Oncology A reduction of BM stem cells, a side effect of chemotherapeutics and antivirals–eg, AZT; BMS leads to ↓ WBCs, RBCs and platelets, ergo, anemia, bacterial infections and spontaneous or excess bleeding

Bone marrow suppression

A decrease in cells responsible for providing immunity, carrying oxygen, and those responsible for normal blood clotting.
References in periodicals archive ?
Thus we suggest that every aplastic anemia patient should be screened for HIV infection, as HIV infection itself may lead to bone marrow suppression and respond to ART only.
Administration of 100 and 200 mg/kg CCT led to marked proliferation and hypercellularity of immature myeloid elements after mice were treated with CP, as well as mitigated bone marrow suppression (Figures 2(b) and 2(c)).
Although CBC values were normal after RAI treatment, the statistical results showed that RAI doses were important for bone marrow suppression. Therefore, physicians should be careful regarding additive or overdoses.
As the patient tolerated the dose of temozolomide without nausea, vomiting, or evidence of bone marrow suppression, her dose was increased to 200 mg per square meter of BSA for 5 days during each 28day cycle.
The child, who arrived at the hospital in a state of coma and shock, displayed bone marrow suppression, rhabdomyolysis, and hepatocellular injuries which were symptomatic of acute valproic acid poisoning.
All of the immunosuppressant drugs can suppress the bone marrow cells at high doses, but severe bone marrow suppression is uncommon in low-dose therapy, and frequent blood monitoring can help in early detection or prevention.
Of 127 test patients who failed to respond to traditional chemical and radiation treatments, about 60 percent have gone into remission without the hair loss, nausea and bone marrow suppression seen in traditional CLL therapies.
However, the physiopathology of the bone marrow suppression in this disease is still unclear.
* Interferon alpha (with or without the addition of low-dose chemotherapeutic agents such as cytosine arabinoside), which augmented the body's immune response against the tumour, as well as directly causing bone marrow suppression. This was more successful than hydroxyurea with longer overall survival rates; notably cytogenetic responses were observed that suggest-ed that the natural history of the disease was being modified.
However, allopurinol isn't always effective for achieving target serum urate levels and concerns about intolerance based on reports of severe hypersensitivity syndrome, rash, gastrointestinal problems, increases in liver enzymes, and bone marrow suppression, tend to scare physicians away from prescribing higher doses, he noted.
Although dosing up to 800 mg/day is acceptable, concerns about intolerance based on reports of severe hypersensitivity syndrome, rash, gastrointestinal problems, increases in liver enzymes, and rare bone marrow suppression tend to scare physicians away from prescribing higher doses, he noted.
With the exception of Fas and sFas-L results, other changes could better be explained by bone marrow suppression with varicella infection because of their similarity.

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