marrow fibrosis

(redirected from bone marrow fibrosis)

marrow fibrosis

A general term for the presence of increased reticulin in the bone marrow, which causes spindling of the marrow cells.

Aetiology
Systemic mastocytosis, cancer (carcinoma, lymphoma, myeloma, myeloproliferative disorders), HIV.

References in periodicals archive ?

Assessments include measuring changes in spleen volume, patient reported total symptom scores, mutant allele burden, inflammatory cytokines as well as bone marrow fibrosis over the course of the treatment period.

Imago BioSciences passes US FDA's approval of IND Application of IMG-7289 for Myeloid Malignancies

2 The characteristic signs of this disease include bone marrow fibrosis, anaemia, splenomegaly, bone pain, night sweats and tear drop cells in the blood film.

Paediatrics primary myelofibrosis and acute stroke: A rare presentation

For bone marrow fibrosis, the difference was not statistically significant (p>0.

The healing effect of bone marrow-derived stem cells in acute radiation syndrome

Al-Ibrahimi conducted successful bone marrow transplants on 12 Bahraini children in Jordan over the past years -- 2 cases of leukemia, 5 cases of Thalassemia, 1 case of bone marrow failure syndrome, 1 case of Bone marrow fibrosis, 1 case of Gideak Hakashy Syndrome and one case of Autologous bone marrow transplant.

Latest blood therapies highlighted

The possible mechanism of PHPT causing anemia and marrow fibrosis is that PTH has a stimulatory effect on marrow fibroblasts, leading to bone marrow fibrosis, but also to the release of cytokines IL-6 and TNF-[alpha] from the osteoclasts that play an indirect role in the pathogenesis of fibrosis [7, 8, 18].

Hungry bone syndrome--a foreseen complication: theory versus practice

Subtle focal intrasinusoidal collections of the cells, active bone remodelling and bone marrow fibrosis were also noted in these subcortical areas.

Bone marrow metastasis of prostatic adenocarcinoma with post-treatment foamy-like changes: a diagnostic pitfall

To study the bone marrow fibrosis biopsy sections are stained by Gomori's reticulin method.

Utility of hematological and laboratory data in assessment of immediate prognosis in multiple myeloma

Only 1 case of scleroderma and 1 case of rheumatoid arthritis had significant bone marrow fibrosis.

Bone marrow examination for unexplained cytopenias reveals nonspecific findings in patients with collagen vascular disease

Objective: Bone marrow fibrosis is the second most common complication that causes morbidity and mortality in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs).

The association between JAK2V617F mutation and bone marrow fibrosis at diagnosis in patients with philadelphia-negative chronic myeloproliferative neoplasms / Philadelphia Negatif kronik Miyeloproliferatif Neoplazili Hastalarin Tanisinda JAK2V617F mutasyonu ile Kemik Iligindeki Fibrozun Iliskisi

In summary, the MPNs are involved with one or more of the following features: overproduction of one or more cell lines, hypercellular marrow or bone marrow fibrosis, cytogenetic abnormalities, point mutations, extramedullary hematopoiesis, hemorrhagic bleeding and or thrombosis and can transform into an acute leukemia.

Myeloproliferative neoplasms: an overview

When PTH levels are under control and bone marrow fibrosis is minimal, most patients respond to conventional doses of Epoetin alfa.

Anemia management in patients with chronic conditions that affect erythropoiesis: case study of the anemic patient