marrow fibrosis

(redirected from bone marrow fibrosis)

marrow fibrosis

A general term for the presence of increased reticulin in the bone marrow, which causes spindling of the marrow cells.

Aetiology
Systemic mastocytosis, cancer (carcinoma, lymphoma, myeloma, myeloproliferative disorders), HIV.
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References in periodicals archive ?
In addition to improvements in spleen volume and constitutional symptoms, the interim data suggest improvements in anemia, transfusion dependence, and bone marrow fibrosis.
Constellation Pharmaceuticals Announces Second-Quarter and Six-Month 2019 Financial Results
These two patients have remained transfusion independent for more than 69 and 24 weeks, respectively, as of April 17 and remain on trial.mTen patients were evaluable for bone marrow fibrosis, of which six experienced improvement in bone marrow morphology of at least one point on a scale of 0-3.
Constellation Pharmaceuticals announces presentation of MANIFEST data at ASCO
Thrombocytopenia with mild bone marrow fibrosis accompanied by fever, pleural effusion, ascites and hepatosplenomegaly.
TAFRO Syndrome - A Specific Subtype of Castleman's Disease in China
Assessments include measuring changes in spleen volume, patient reported total symptom scores, mutant allele burden, inflammatory cytokines as well as bone marrow fibrosis over the course of the treatment period.
Imago BioSciences passes US FDA's approval of IND Application of IMG-7289 for Myeloid Malignancies
These result in the secondary process of bone marrow fibrosis. Bone marrow fibrosis which impairs the normal haematopoietic process causing severe anaemia is the hallmark of Primary Myelofibrosis.4
Paediatrics primary myelofibrosis and acute stroke: A rare presentation
For bone marrow fibrosis, the difference was not statistically significant (p>0.05).
The healing effect of bone marrow-derived stem cells in acute radiation syndrome
Al-Ibrahimi conducted successful bone marrow transplants on 12 Bahraini children in Jordan over the past years -- 2 cases of leukemia, 5 cases of Thalassemia, 1 case of bone marrow failure syndrome, 1 case of Bone marrow fibrosis, 1 case of Gideak Hakashy Syndrome and one case of Autologous bone marrow transplant.
Latest blood therapies highlighted
The possible mechanism of PHPT causing anemia and marrow fibrosis is that PTH has a stimulatory effect on marrow fibroblasts, leading to bone marrow fibrosis, but also to the release of cytokines IL-6 and TNF-[alpha] from the osteoclasts that play an indirect role in the pathogenesis of fibrosis [7, 8, 18].
Hungry bone syndrome--a foreseen complication: theory versus practice
Subtle focal intrasinusoidal collections of the cells, active bone remodelling and bone marrow fibrosis were also noted in these subcortical areas.
Bone marrow metastasis of prostatic adenocarcinoma with post-treatment foamy-like changes: a diagnostic pitfall
European consensus on grading bone marrow fibrosis and assessment of cellularity.
Utility of hematological and laboratory data in assessment of immediate prognosis in multiple myeloma
Objective: Bone marrow fibrosis is the second most common complication that causes morbidity and mortality in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs).
The association between JAK2V617F mutation and bone marrow fibrosis at diagnosis in patients with philadelphia-negative chronic myeloproliferative neoplasms / Philadelphia Negatif kronik Miyeloproliferatif Neoplazili Hastalarin Tanisinda JAK2V617F mutasyonu ile Kemik Iligindeki Fibrozun Iliskisi
In summary, the MPNs are involved with one or more of the following features: overproduction of one or more cell lines, hypercellular marrow or bone marrow fibrosis, cytogenetic abnormalities, point mutations, extramedullary hematopoiesis, hemorrhagic bleeding and or thrombosis and can transform into an acute leukemia.
Myeloproliferative neoplasms: an overview

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