marrow fibrosis

(redirected from bone marrow fibrosis)

marrow fibrosis

A general term for the presence of increased reticulin in the bone marrow, which causes spindling of the marrow cells.

Aetiology
Systemic mastocytosis, cancer (carcinoma, lymphoma, myeloma, myeloproliferative disorders), HIV.
References in periodicals archive ?
Assessments include measuring changes in spleen volume, patient reported total symptom scores, mutant allele burden, inflammatory cytokines as well as bone marrow fibrosis over the course of the treatment period.
2 The characteristic signs of this disease include bone marrow fibrosis, anaemia, splenomegaly, bone pain, night sweats and tear drop cells in the blood film.
For bone marrow fibrosis, the difference was not statistically significant (p>0.
Al-Ibrahimi conducted successful bone marrow transplants on 12 Bahraini children in Jordan over the past years -- 2 cases of leukemia, 5 cases of Thalassemia, 1 case of bone marrow failure syndrome, 1 case of Bone marrow fibrosis, 1 case of Gideak Hakashy Syndrome and one case of Autologous bone marrow transplant.
The possible mechanism of PHPT causing anemia and marrow fibrosis is that PTH has a stimulatory effect on marrow fibroblasts, leading to bone marrow fibrosis, but also to the release of cytokines IL-6 and TNF-[alpha] from the osteoclasts that play an indirect role in the pathogenesis of fibrosis [7, 8, 18].
Subtle focal intrasinusoidal collections of the cells, active bone remodelling and bone marrow fibrosis were also noted in these subcortical areas.
To study the bone marrow fibrosis biopsy sections are stained by Gomori's reticulin method.
Only 1 case of scleroderma and 1 case of rheumatoid arthritis had significant bone marrow fibrosis.
In summary, the MPNs are involved with one or more of the following features: overproduction of one or more cell lines, hypercellular marrow or bone marrow fibrosis, cytogenetic abnormalities, point mutations, extramedullary hematopoiesis, hemorrhagic bleeding and or thrombosis and can transform into an acute leukemia.
Effect of serum parathyroid hormone and bone marrow fibrosis on the response to erythropoietin in uremia.
When PTH levels are under control and bone marrow fibrosis is minimal, most patients respond to conventional doses of Epoetin alfa.

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