marrow fibrosis

(redirected from bone marrow fibrosis)

marrow fibrosis

A general term for the presence of increased reticulin in the bone marrow, which causes spindling of the marrow cells.

Aetiology
Systemic mastocytosis, cancer (carcinoma, lymphoma, myeloma, myeloproliferative disorders), HIV.
References in periodicals archive ?
Treated mice showed reduced splenomegaly, decreased platelet counts, a marked reduction in key cytokines, a resolution of bone marrow fibrosis and a reduction of mutant allele burden over the course of the 4 week treatment period.
Subtle focal intrasinusoidal collections of the cells, active bone remodelling and bone marrow fibrosis were also noted in these subcortical areas.
Only 1 case of scleroderma and 1 case of rheumatoid arthritis had significant bone marrow fibrosis.
In summary, the MPNs are involved with one or more of the following features: overproduction of one or more cell lines, hypercellular marrow or bone marrow fibrosis, cytogenetic abnormalities, point mutations, extramedullary hematopoiesis, hemorrhagic bleeding and or thrombosis and can transform into an acute leukemia.
Effect of serum parathyroid hormone and bone marrow fibrosis on the response to erythropoietin in uremia.
Other risks for Promacta include: bone marrow reticulin formation and risk for bone marrow fibrosis, thrombotic/thromboembolic complications, hematologic malignancies, and cataracts.
Because of the risk of hepatotoxicity, and other risks including bone marrow reticulin and risk for bone marrow fibrosis, thrombotic/thromboembolic complications, recurrence of thrombocytopenia and hemorrhage risk after PROMACTA cessation, hematologic malignancies and progression of malignancies, and cataracts, PROMACTA is available only through a restricted distribution program called PROMACTA CARES.
Chronic idiopathic myelofibrosis is a myeloproliferative disorder characterized by splenomegaly, myeloid metaplasia and reactive bone marrow fibrosis.
In addition, no cases of bone marrow fibrosis were reported.
Idiopathic primary myelofibrosis is a chronic disorder characterized by bone marrow fibrosis, extramedullary hematopoiesis, and a leukoerythroblastic blood profile, and it is usually classified as a myeloproliferative syndrome.
Clinical studies have not excluded a risk of bone marrow fibrosis with cytopenias.

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