Osteosarcomas arise in several clinical settings, which include pre-existing bone abnormalities such as Paget's disease, fibrous dysplasia, giant cell tumour, multiple osteochondroma, bone infarct
, chronic osteomyelitis, osteogenesis imperfecta, and a history of radiation exposure.
5) Osteosarcomas arise in several clinical settings, including pre-existing bone abnormalities such as Paget's disease, fibrous dysplasia, giant cell tumor, multiple osteochondroma, bone infarct
, chronic osteomyelitis, osteogenesis imperfecta, and with history of radiation exposure.
Avascular necrosis of long bones, persistence of red marrow, intra-medullary bone hyperplasia and bone infarcts
are some of the common musculoskeletal abnormalities seen in SCD.
Some patients have acute generalized body pain while others have localized bony pain resulting from bone infarcts .
There was bone resorption of greater trochanters of both femoral bones and lateral ends of the clavicles but there were no bone infarcts or avascular necrosis of the femoral heads as would be anticipated in SCD (Figures 8 and 9).
Fracture complicating bone infarcts
and/or osteomyelitis in sickle cell disease.
Dactylitis can occur in seronegative arthropathies, such as psoriatic arthritis and ankylosing spondylitis, in sickle-cell disease as result of a vasoocclusive crisis with bone infarcts
, and in infectious conditions including tuberculosis and leprosy (6).
Possible associations with Paget' s disease or bone infarcts
have also been described.
Bone involvement may also lead to bone pain and pathologic fractures, bone infarcts
, and osteonecrosis.