(20) Several pathogeneses have been suspected in people, including posttraumatic bone reaction, healing of bone infarct
, and a true benign tumor.
The most common causes of bone infarct
or osteonecrosis include trauma, corticosteroids, sickle cell disease and idiopathic.
Osteosarcomas arise in several clinical settings, which include pre-existing bone abnormalities such as Paget's disease, fibrous dysplasia, giant cell tumour, multiple osteochondroma, bone infarct
, chronic osteomyelitis, osteogenesis imperfecta, and a history of radiation exposure.
(5) Osteosarcomas arise in several clinical settings, including pre-existing bone abnormalities such as Paget's disease, fibrous dysplasia, giant cell tumor, multiple osteochondroma, bone infarct
, chronic osteomyelitis, osteogenesis imperfecta, and with history of radiation exposure.
This process of "creeping substitution" mimics the way in which necrotic bone is resorbed and replaced after a fracture or bone infarct
. With allograft tissue, resorption and new bone formation occur first beneath periosteum and at the interface between graft and host.
Avascular necrosis of long bones, persistence of red marrow, intra-medullary bone hyperplasia and bone infarcts
are some of the common musculoskeletal abnormalities seen in SCD.MRI is indicated for detailed assessment of musculoskeletal abnormalities but was not done due to cost issues.
Some patients have acute generalized body pain while others have localized bony pain resulting from bone infarcts .
There was bone resorption of greater trochanters of both femoral bones and lateral ends of the clavicles but there were no bone infarcts or avascular necrosis of the femoral heads as would be anticipated in SCD (Figures 8 and 9).
Fracture complicating bone infarcts
and/or osteomyelitis in sickle cell disease.
Dactylitis can occur in seronegative arthropathies, such as psoriatic arthritis and ankylosing spondylitis, in sickle-cell disease as result of a vasoocclusive crisis with bone infarcts
, and in infectious conditions including tuberculosis and leprosy (6).
Possible associations with Paget' s disease or bone infarcts
have also been described.
Bone involvement may also lead to bone pain and pathologic fractures, bone infarcts
, and osteonecrosis.