BGLAP

(redirected from bone gamma-carboxyglutamate)

BGLAP

A gene on chromosome 1q25-q31 that encodes a protein which constitutes 1–2% of bone protein, which binds strongly to apatite and calcium.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
The genes displayed elevated expression also included runt-related transcription factor 2 (RunX2:2.26-fold), ENPP1 (1.95-fold), and bone gamma-carboxyglutamate (gla) protein/osteocalcin (BGLAP/osteocalcin: 1.87-fold), all of which were previously implicated in OA or pathological calcification associated with OA [36-39].
Osteocalcin, also called bone gamma-carboxyglutamate (Gla) protein, is a small, noncollagenous protein that is specific for bone tissue and dentin, but its precise function remains unknown.[8] Osteocalcin is synthesized predominantly by the osteoblast and is mostly incorporated into the extracellular matrix of the bone.