To test how the cells grow on the scaffold itself, the team incubated cultured bone cells
on its surface for different lengths of time.
So "since our bone cells
interact with nanometer bumps, we need materials that have nanometer bumps," says Tom Webster, a member of the Purdue research team.
By contrast, NELL-1 encourages stem cells to form bone cells
instead of fat cells.
"Because MSCs harvested from adult bone marrow are a heterogeneous population of cells and their ability to undergo differentiation into cartilage or bone cells
varies from donor to donor, our findings have significant implication for MSC-based strategies for engineering cartilage and bone tissue," Shastri said.
ViBone is processed using a proprietary method optimized to protect and preserve the health of native bone cells
to potentially enhance new bone formation.
* Bone cells
develop, creating a hard, protective shell.
Literature was found deficient in observing the effects of injury on the bone cells
To test the premise, investigators placed stem cells at their normal volume in a hardened hydrogel substrate to simulate the rigidness of bone cells
. After one week, a large portion of the stem cells developed into pre-bone cells.
When you put stem cells on our scaffolds, they turn into bone cells
and start to up-regulate their expression of bone specific genes.
Like living bone cells
in the body, the resulting osteoblasts built bone tissues with blood vessels.
It has made key achievements in the making of skin cells for treatment of burns and malformation, making human bone cells
and cells related to eye surgery as well as working to implement the knee cartilage regeneration therapy and cornea regeneration and multiple sclerosis projects .