In patients with idiopathic CPP, the 2nd year height SDS was significantly lower compared to the beginning of treatment (1.05[+ or -]1.03 and 0.74[+ or -]1.06, p=0.024); whereas, height SDS according to bone age
was significantly higher in the 2nd year compared to the beginning of treatment (-1.01[+ or -]0.95 and -0.68[+ or -]0.72, p=0.03).
Kim et al., "Effects of adrenal androgen levels on bone age
advancement in prepubertal children: using the Ewha birth and growth cohort study," Journal of Korean Medical Science, vol.
The correlation coefficients for vertebral bone age
and hand-wrist bone age
were 0.825 and 0.856 (P < 0.001) for girls and boys, respectively (Fig.
Partial correlation analysis was also applied to examine these relationships after adjusting for bone age
(Baptista et al., 2016).
Follow-up examination did not reveal an electrolyte disorder; the Tanner stage and bone age
remained stable, and the levels of 17-OH progesterone dropped from 52.00 to 28.00 ng/ dL after 1 year and 3 months of treatment.
Clinical features of 11-[beta]-hydroxylase deficiency in childhood might be premature pubarche and accelerated bone age
, all of which occurred in our patient.
This maybe associated with the delayed bone age
observed in patients with CF .
development index was 40, while bone age
showed 6-10 years old.
Some of those theories are related to retardation in CNS maturation psychogenic and behavioral components environmental factors allergens low urinary bladder capacity deep sleep disorder structural anomalies of urinary tract uninhibited neurogenic contractions defects in diurnal secretion of vasopressin prostaglandin production disorders and sleep apnea syndrome.1617 Retardation in the growth rate decreased bone age
and bone mineral density identified in children with nocturnal enuresis may reflect delayed maturation of regulatory central nervous system functions.18 It is a well known fact that vitamin B12 deficiency can result
Assessment (BAA) often expressed as skeletal age assessment is a clinical method for evaluating the stage of skeletal maturation of a child .
As LCP patients tend to have delayed bone age
, on average 2 years in girls and 1 year in boys, (6) their femoral head ossific nuclei are smaller than those in children of similar chronologic age.
Body weight is associated with bone age
as an independent variable for CTX and osteocalcin (20).