Proniewicz, "Phe-MetNH2 terminal bombesin
subfamily peptides: potential induced changes in adsorption on Ag, Au, and Cu electrodes monitored by SERS," Journal of Physical Chemistry C, vol.
Mantey et al., "Bombesin
marine toxin conjugates inhibit the growth of lung cancer cells," Life Sciences, vol.
The cerebral ganglion of ascidians has been shown to have many neurons immunoreactive for vertebrate neuropeptides such as GnRH, bombesin
, and neurotensin (11, 12].
HSP27 is a mediator of sustained smooth muscle contraction in response to bombesin
Receptors suchas SSTR, NCA-90, integrins, folate, bombesin
, vascular cell adhesion protein-1, and interleukins expressed by activated T-cells, CXCR2 expressed on neutrophils, and CXCR4 overexpressed by leukocytes have demonstrated potential for in vivo targeted imaging .
Analyzing various cancer cell types such as MDA-MB-468 breast carcinoma, PC-3 prostate carcinoma, and SW 480 colon carcinoma cells, there have been identified both inducers for the migration activity, such as norepinephrine, dopamine, substance P, met-enkephalin, and bombesin
, as well as inhibitors such as gamma-aminobutyric acid (GABA).
Recent studies have described all four subtypes of Gq/11 coupled GPCRs, including the muscarinic 1,3, and 5 (M1, M3, and M5) receptors; bombesin
receptor, vasopressin receptor, endothelin receptor, thyrotropin-releasing hormone receptor (TRHR), gonadotropin-releasing hormone receptor (GnRHR), membrane estrogen receptor (mER), chemokine receptors, adrenergic receptors ([alpha]1AR), and angiotensin II type 1 receptor (AT(1)R) [11-13].
The neuropeptide bombesin
consists of 14 amino acids and is analogous to GRP, differing in only 1 of 10 carboxy-terminal residues.
Regulation and signaling of human bombesin
receptors and their biological effects.
The AST-A receptors are related to the vertebrate galanin receptors , the AST-B receptors to the bombesin
receptors , and the AST-C receptors show similarity to the somatostatin/opioid receptors [117,118].
Rozengurt, "Reduced requirement of mitogen-activated protein kinase (MAPK) activity for entry into the S phase of the cell cycle in Swiss 3T3 fibroblasts stimulated by bombesin
and insulin," The Journal of Biological Chemistry, vol.