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a tetradecapeptide neurotransmitter and hormone found in the brain and intestine; it is also found increased in cultures of small cell carcinoma of the lung.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
Pharmacologically active tetradecapeptide found in skins of European amphibians of the family Discoglossidae, principally Bombina bombina and B. variegata variegata. A potent stimulant of gastric and pancreatic secretions; a bombesinlike immunoreactive peptide is found in both brain and gut. Other actions include hypertensive, antidiuretic, and hyperglycemic activity. Has a strong effect on core temperature lowering in rats. High levels of intracellular bombesin have also been found in human small-cell lung carcinoma.
Farlex Partner Medical Dictionary © Farlex 2012
bombesinA 14-residue neuropeptide hormone produced in the gastric antrum that stimulates gastrointestinal (GI) smooth muscle contraction and the release of gastric acid and GI hormones. Bombesin also acts on vasculature, gallbladder, pancreas, lung and urinary tract; in the cerebral cisterna it evokes hypothermia, analgesia, hyperglucagonaemia, hyperglycaemia, and stimulates proliferation of bronchial epithelial cells, pancreas, small cell carcinoma and thyroid tumours. Bombesin staining occurs in two-thirds of carcinoids and neuroendocrine tumours, including small cell carcinoma of the lung
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.