bombesin


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Related to bombesin: Motilin, dyshormonogenetic goiter

bombesin

 [bom´bĕ-sin]
a tetradecapeptide neurotransmitter and hormone found in the brain and intestine; it is also found increased in cultures of small cell carcinoma of the lung.

bom·be·sin

(bomb'ĕ-sin),
Pharmacologically active tetradecapeptide found in skins of European amphibians of the family Discoglossidae, principally Bombina bombina and B. variegata variegata. A potent stimulant of gastric and pancreatic secretions; a bombesinlike immunoreactive peptide is found in both brain and gut. Other actions include hypertensive, antidiuretic, and hyperglycemic activity. Has a strong effect on core temperature lowering in rats. High levels of intracellular bombesin have also been found in human small-cell lung carcinoma.

bombesin

A 14-residue neuropeptide hormone produced in the gastric antrum that stimulates gastrointestinal (GI) smooth muscle contraction and the release of gastric acid and GI hormones. Bombesin also acts on vasculature, gallbladder, pancreas, lung and urinary tract; in the cerebral cisterna it evokes hypothermia, analgesia, hyperglucagonaemia, hyperglycaemia, and stimulates proliferation of bronchial epithelial cells, pancreas, small cell carcinoma and thyroid tumours. Bombesin staining occurs in two-thirds of carcinoids and neuroendocrine tumours, including small cell carcinoma of the lung
References in periodicals archive ?
Proniewicz, "Phe-MetNH2 terminal bombesin subfamily peptides: potential induced changes in adsorption on Ag, Au, and Cu electrodes monitored by SERS," Journal of Physical Chemistry C, vol.
Mantey et al., "Bombesin marine toxin conjugates inhibit the growth of lung cancer cells," Life Sciences, vol.
The cerebral ganglion of ascidians has been shown to have many neurons immunoreactive for vertebrate neuropeptides such as GnRH, bombesin, and neurotensin (11, 12].
HSP27 is a mediator of sustained smooth muscle contraction in response to bombesin. Biochem.
Receptors suchas SSTR, NCA-90, integrins, folate, bombesin, vascular cell adhesion protein-1, and interleukins expressed by activated T-cells, CXCR2 expressed on neutrophils, and CXCR4 overexpressed by leukocytes have demonstrated potential for in vivo targeted imaging [108].
Analyzing various cancer cell types such as MDA-MB-468 breast carcinoma, PC-3 prostate carcinoma, and SW 480 colon carcinoma cells, there have been identified both inducers for the migration activity, such as norepinephrine, dopamine, substance P, met-enkephalin, and bombesin, as well as inhibitors such as gamma-aminobutyric acid (GABA).
Tenders invited for Supply of bombesin (1-14) analogue, n- terminal dota,aa sequence pro-gln-arg-tyr-gly-asn-gln-trp-ala-val-gly-his-leu-met,residues 14, c-terminal nh2 , peptidename: bombesin (1-14) analogue, n-terminal: dota, c-terminal: nh2, residues: 14, purity: greater than 95% as per annexure a
Recent studies have described all four subtypes of Gq/11 coupled GPCRs, including the muscarinic 1,3, and 5 (M1, M3, and M5) receptors; bombesin receptor, vasopressin receptor, endothelin receptor, thyrotropin-releasing hormone receptor (TRHR), gonadotropin-releasing hormone receptor (GnRHR), membrane estrogen receptor (mER), chemokine receptors, adrenergic receptors ([alpha]1AR), and angiotensin II type 1 receptor (AT(1)R) [11-13].
The neuropeptide bombesin consists of 14 amino acids and is analogous to GRP, differing in only 1 of 10 carboxy-terminal residues.
Regulation and signaling of human bombesin receptors and their biological effects.
The AST-A receptors are related to the vertebrate galanin receptors [115], the AST-B receptors to the bombesin receptors [116], and the AST-C receptors show similarity to the somatostatin/opioid receptors [117,118].
Rozengurt, "Reduced requirement of mitogen-activated protein kinase (MAPK) activity for entry into the S phase of the cell cycle in Swiss 3T3 fibroblasts stimulated by bombesin and insulin," The Journal of Biological Chemistry, vol.