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a tetradecapeptide neurotransmitter and hormone found in the brain and intestine; it is also found increased in cultures of small cell carcinoma of the lung.
Pharmacologically active tetradecapeptide found in skins of European amphibians of the family Discoglossidae, principally Bombina bombina and B. variegata variegata. A potent stimulant of gastric and pancreatic secretions; a bombesinlike immunoreactive peptide is found in both brain and gut. Other actions include hypertensive, antidiuretic, and hyperglycemic activity. Has a strong effect on core temperature lowering in rats. High levels of intracellular bombesin have also been found in human small-cell lung carcinoma.
bombesin/bom·be·sin/ (bom´bĕ-sin) a tetradecapeptide neurotransmitter and hormone found in the brain and gut.
a neurohormone and pressor substance found in small amounts in brain and intestinal tissue under normal conditions and in increased amounts in certain pulmonary and thyroid tumors. It is a potent mitogen and its effects on gastrin and other hormones are attributed to increased cell numbers.
bombesinA 14-residue neuropeptide hormone produced in the gastric antrum that stimulates gastrointestinal (GI) smooth muscle contraction and the release of gastric acid and GI hormones. Bombesin also acts on vasculature, gallbladder, pancreas, lung and urinary tract; in the cerebral cisterna it evokes hypothermia, analgesia, hyperglucagonaemia, hyperglycaemia, and stimulates proliferation of bronchial epithelial cells, pancreas, small cell carcinoma and thyroid tumours. Bombesin staining occurs in two-thirds of carcinoids and neuroendocrine tumours, including small cell carcinoma of the lung
a tetradecapeptide found in the brain and gut.