bolus injection

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bolus injection

The injection of drug in a single large volume (a bolus), as in an IV infusion, in contrast to gradual administration.
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Comparison of time taken (in minutes) to reach TOF 0 and also recovery to reach TOF3 after bolus infusion of Vecuronium and Atracurium Time (Min.) Group V After bolus dose 4.2 [+ or -] 0.9 To TOF '0' After bolus dose 53.8 [+ or -] 9.8 To TOF '1' After starting 12.6 [+ or -] 2.9 infusion to TOF '0' After stopping 62.2 [+ or -] 17.7 infusion to TOF 3 Time (Min.) Group A p Value After bolus dose 4.3 [+ or -] 0.8 0.712 To TOF ' 0' After bolus dose 38.7 [+ or -] 6.8 <.0001** To TOF '1' After starting 16.1 [+ or -] 3.1 <0.0007* infusion to TOF '0' After stopping 27.9 [+ or -] 6.7 < 0.0001** infusion to TOF 3 * p value < 0.05 is significant, ** highly significant Table 2.
The incidence of side effects may be reduced by applying a slow infusion instead of a rapid bolus infusion or by reducing the bolus dose from 2 mg to 1 mg (24).
In addition, in antibiotics in which minimal inhibitory concentration is important (as in cephalosporins), slow oral absorption may be as effective as intravenous bolus infusion (5, 6).
Bolus infusion of 400 ng/kg ANGII increased mean [P.sub.DA] to 27.1 [+ or -] 2.7 mmHg from a baseline of 14.7 [+ or -] 2.5 mmHg (P < 0.05) (Fig.
Prior studies have shown that using a higher cumulative anthracycline dose when administered as a bolus infusion increases the risk of cardiotoxicity in children and adults [8, 9].
administered epidural bolus infusion of fentanyl (4 mcg / mL) to the first group of levobupivacaine (0.125%) to the second group and of a combination of levobupivacaine (0.125%) + fentanyl (4 mcg / mL ) to the third group.
Muir, "Does alteplase bolus infusion delay affect outcome?" International Journal of Stroke, vol.
When shock is diagnosed fluid resuscitation should commence with a rapid (over 5 - 10 min) bolus infusion of 20 ml/kg isotonic crystalloid, e.g.
And since bolus infusion is as effective as continuous infusion, many may switch to bolus treatment because it is more convenient, he said.
A slow bolus infusion of low dose tolazoline (0.5 mg-2 mg/kg) mixed with plasmanate or normal saline (10 mL/kg) was administered.
The onset of action is within 30 seconds after bolus infusion with duration of action from 3 to 10 minutes.
Accordingly, we conducted a controlled, randomised, cross-over large animal experiment to investigate the effects of a bolus infusion of one litre of normal saline or one litre of Gelofusine[R] on systemic haemodynamics, regional blood flows and regional oxygen delivery.