blue sclera


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Related to blue sclera: osteogenesis imperfecta

sclera

 [skle´rah] (L.)
the tough, white outer coat of the eyeball, covering approximately the posterior five-sixths of its surface, continuous anteriorly with the cornea and posteriorly with the external sheath of the optic nerve. adj., adj scle´ral.
The sclera and other eye structures. From Lammon et al., 1995.
blue sclera abnormal blueness of the sclera; it is a prominent feature of osteogenesis imperfecta and is also seen in certain other conditions. (See Atlas 1, Part B.)

blue scle·ra

appearance of the uveal tissue through a thin sclera seen in a number of conditions including myopia, buphthalmos, scleral staphyloma, Ehlers-Danlos syndrome, Marfan syndrome, osteogenesis imperfecta, Paget disease, and Pierre Robin syndrome.
Sclera of variable thickness that retain the normal fetal transparency so that the blue uvea is visible. Blue sclera occur alone or with brittle bones and deafness; many are autosomal dominant
DiffDx Blue sclera may also be seen in AIDS embryopathy, Bloch-Sulzberger syndrome, Crouzon syndrome, Cornelia de Lange syndrome, Ehlers-Danlos syndrome, Foelling syndrome, Laron dwarfism—Loja type—Lowe syndrome, Marfan syndrome, pseudohypoparathyroidism, Turner syndrome, and Werner syndrome

blue sclera

An abnormal thinning of the sclera through which a blue uveal pigment is seen. This may be found in people with disorders of collagen formation such as osteogenesis imperfecta.
See also: sclera
References in periodicals archive ?
The range is so wide because mild OI often goes unrecognized: One patient went 64 years before being diagnosed, and a 21-year-old patient with unmistakable blue sclera was undiagnosed through adolescence, induction into the Army, and service in Iraq.
Other symptoms include: "loose" joints, low muscle tone, a tendency toward easy bruising, translucent skin, a barrel-shaped rib cage, excessive sweating, and blue sclera.
Osteogenesis imperfecta (fragilitas ossium) is an inherited connective tissue disorder characterized by osteoporosis, blue sclera, poor dentition, and mixed deafness.
(1,2,3) Other features noted are (1) craniofacial abnormalities like craniosynostosis, malar hypoplasia, cleft palate, blue sclera, micrognathia and/or retrognathia.