blood-testis barrier


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barrier

 [bar´e-er]
1. an obstruction.
2. a partition between two fluid compartments in the body.
3. a covering used to prevent contact with body fluids.
alveolar-capillary barrier (alveolocapillary barrier) see under membrane.
blood-air barrier alveolocapillary membrane.
blood-aqueous barrier the physiologic mechanism that prevents exchange of materials between the chambers of the eye and the blood.
blood-brain barrier see blood-brain barrier.
blood-gas barrier alveolocapillary membrane.
blood-testis barrier a barrier separating the blood from the seminiferous tubules, consisting of special junctional complexes between adjacent Sertoli cells near the base of the seminiferous epithelium.
barrier methods contraceptive methods such as condoms and diaphragms in which a plastic or rubber barrier blocks passage of spermatozoa through the vagina or cervix. See discussion under contraception.
placental barrier the tissue layers of the placenta which regulate the exchange of substances between the fetal and maternal circulation.

blood-testis barrier

an occluding barrier formed by Sertoli cells in the seminiferous tubules of the testis, which separates the more mature cells of spermatogenesis in the adlumenal compartment of the tubule from blood-derived products in the basal compartment.
References in periodicals archive ?
Scully, "Passage of leptin across the blood-testis barrier," American Journal of Physiology-Endocrinology and Metabolism, vol.
Mruk et al., "Tumor necrosis factor a reversibly disrupts the blood-testis barrier and impairs Sertoligerm cell adhesion in the seminiferous epithelium of adult rat testes," Journal of Endocrinology, vol.
The blood-testis barrier and its implications for male contraception.
It is possible that these Sertoli cell lesions lead to a disruption of the blood-testis barrier, allowing the subsequent passage of antigens from the tubular lumen to the testicular interstitium.
"Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: Novel insights from studies on Eps8 and Arp3," Biochemical Journal 435(3): 553-562.
This might imply that these drugs have been able to permeate through the blood-testis barrier and cause arrest of spermatogenesis (51).
"Connexin 43 is critical to maintain the homeostasis of the blood-testis barrier via its effects on tight junction reassembly," Proceedings of the National Academy of Sciences of the United States of America 107(42): 17998-18003.
In the case of the male reproductive organs, it might presumably cross the blood-testis barrier and damage germ and Sertoli cells, thus altering normal spermatogenesis and sperm production.
"Regulation of blood-testis barrier dynamics by focal adhesion kinase (FAK): An unexpected turn of events," Cell Cycle 8(21): 3493-3499.
"Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics," Proceedings of the National Academy of Sciences of the United States of America 106(25): 10213-10218.
"Interleukin 1 Alpha (IL1A) is a novel regulator of the blood-testis barrier in the rat," Biology of Reproduction 78(3): 445-454.