Chronic myeloid leukaemia (CML) is a myeloproliferative disorder predominantly of adult life, having a male preponderance.1 These patients have variable presentations.2 Some are completely asymptomatic, their disease being diagnosed incidentally on routine blood CP while others may have symptoms due to anemia or splenomegaly.3 CML is usually diagnosed on peripheral blood film
but the detection of the BCR-ABL fusion transcript by molecular techniques is necessary for establishing a definitive diagnosis.4
The basic investigation in the suspected cases of megaloblastic anaemia with pancytopenia include complete blood counts, peripheral blood film
examination, reticulocyte count and cobalamin and folate assay.
The diagnosis of TTP in our study was done by demonstration of significant schistocytes (more than 1 percent) on peripheral blood film
. The patients were treated with steroids and plasma pheresis and in some cases with weekly Rituximab for 4 weeks.
Her blood film
showed basophilic stippling that was morphologically distinct from Pappenheimer bodies or Howell Jolly bodies.
Microscopic examination of wet blood film
revealed presence of larva of Setaria spp.
Clarke and Cheung described a case of metastatic lobular breast cancer diagnosed on a peripheral blood film
. (7) The authors described only a scattered infiltrate of these cells in the bone marrow, though, unlike our patient.
For malaria parasites examination, two drops of blood was put on clean glass slide to prepare thick film and thin blood film
and then air-dried in a horizontal position.
Normal coagulation profile, normal fibrinogen level, and absence of schistocytes in the peripheral blood film
were against DIC.
A blood film
confirmed neutrophilia and left shift and markedly microcytic red cells, with no evidence of haematological malignancy.
His blood film
showed marked monocytosis, promonocytes, and some circulating blasts suggesting acute myelomonocytic leukemia (AMML) or chronic myelomonocytic leukemia (CMML) in transformation.
Sickle cell anemia can be diagnosed by the presence of sickle cells (drepanocytes) in the peripheral blood film
with direct microscopic examination.