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an antitumor antibiotic obtained from cultures of Streptomyces verticellus. It binds to DNA and causes single-strand breaks and double-strand scissions, impairing DNA synthesis and inhibiting RNA and protein synthesis. Administered by injection as the sulfate salt to treat lymphomas, soft tissue sarcomas, and cancers of the head and neck, cervix, skin, testes, lung, and other organs.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
Any of a group of antibiotics obtained from the bacterium Streptomyces verticillus. A mixture of them, usually in the form of their sulfate salts, is used as an antineoplastic agent.
Any of a class of antibiotics isolated from the bacterium Streptomyces verticillus, used usually in sulfate form in combination with other drugs to treat certain kinds of cancer.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
bleomycinA chemotherapeutic antibiotic, which consists of a mixture of low molecular weight (±1.5-kD) metal and oxygen-dependent DNA cleavers, isolated from Streptomyces verticillus, which is used to treat lymphomas, Hodgkin’s disease, Kaposi sarcoma, testicular cancer and other germ cell tumours.
Mechanism of action
Induction of single- and double-stranded breaks in DNA.
Fever, stomatitis, skin lesions, marrow suppression, fever, chills and hair loss; fibrosis at > 200 mg/m2 total doses.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
bleomycinBlenoxane, BLEO, BLM Oncology A chemotherapeutic antibiotic, which consists of a mixture of low MW–±1.5 kD metal and oxygen-dependent DNA cleavers, isolated from Streptomyces verticillus verticellus, which is used to treat lymphomas, Hodgkin's disease, Kaposi sarcoma, testicular CA, and other germ cell tumors Mechanism of action Induction of single- and double-stranded breaks in DNA Adverse effects Fever, stomatitis, skin lesions, BM suppression, fever, chills, and hair loss
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
bleomycinA toxic glycopeptide antibiotic that interferes with the synthesis of DNA and is used as an anticancer drug, usually in combination with other drugs. It has some value in HODGKIN'S DISEASE, other LYMPHOMAS and squamous cell cancers of the skin. Side effects include FIBROSIS of the lungs, drying and discoloration of the skin over the back of joints. The drug is on the WHO official list.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005