bleomycin


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Related to bleomycin: cisplatin, doxorubicin

bleomycin

 [ble″o-mi´sin]
an antitumor antibiotic obtained from cultures of Streptomyces verticellus. It binds to DNA and causes single-strand breaks and double-strand scissions, impairing DNA synthesis and inhibiting RNA and protein synthesis. Administered by injection as the sulfate salt to treat lymphomas, soft tissue sarcomas, and cancers of the head and neck, cervix, skin, testes, lung, and other organs.

bleomycin

/ble·o·my·cin/ (ble-o-mi´sin) a polypeptide antibiotic mixture obtained from cultures of Streptomyces verticellus; used as the sulfate salt as an antineoplastic.

bleomycin

(blē′ə-mī′sĭn)
n.
Any of a group of antibiotics obtained from the bacterium Streptomyces verticillus. A mixture of them, usually in the form of their sulfate salts, is used as an antineoplastic agent.

bleomycin

(blē′ə-mī′sĭn)
n.
Any of a class of antibiotics isolated from the bacterium Streptomyces verticillus, used usually in sulfate form in combination with other drugs to treat certain kinds of cancer.

bleomycin

A chemotherapeutic antibiotic, which consists of a mixture of low molecular weight (±1.5-kD) metal and oxygen-dependent DNA cleavers, isolated from Streptomyces verticillus, which is used to treat lymphomas, Hodgkin’s disease, Kaposi sarcoma, testicular cancer and other germ cell tumours.
 
Mechanism of action
Induction of single- and double-stranded breaks in DNA.
 
Adverse effects
Fever, stomatitis, skin lesions, marrow suppression, fever, chills and hair loss; fibrosis at > 200 mg/m2 total doses.

bleomycin

Blenoxane, BLEO, BLM Oncology A chemotherapeutic antibiotic, which consists of a mixture of low MW–±1.5 kD metal and oxygen-dependent DNA cleavers, isolated from Streptomyces verticillus verticellus, which is used to treat lymphomas, Hodgkin's disease, Kaposi sarcoma, testicular CA, and other germ cell tumors Mechanism of action Induction of single- and double-stranded breaks in DNA Adverse effects Fever, stomatitis, skin lesions, BM suppression, fever, chills, and hair loss

bleomycin

A toxic glycopeptide antibiotic that interferes with the synthesis of DNA and is used as an anticancer drug, usually in combination with other drugs. It has some value in HODGKIN'S DISEASE, other LYMPHOMAS and squamous cell cancers of the skin. Side effects include FIBROSIS of the lungs, drying and discoloration of the skin over the back of joints. The drug is on the WHO official list.

bleomycin

a polypeptide antibiotic mixture having antineoplastic properties, obtained from cultures of Streptomyces verticellus. Evidence indicates that bleomycin inhibits cell division, thymidine incorporation into DNA, and DNA synthesis. Has been used in dogs and cats in the treatment of squamous cell carcinoma, but side-effects, including pneumonia or pulmonary scarring, limit its use.
References in periodicals archive ?
The patient described here had reached the maximum tolerable dose of both bleomycin and doxorubicin.
Injection of bleomycin as a primary therapy of cystic lymphangioma.
Table 2 Rheumatic Syndromes Caused by Anti-Neoplastic Therapy Rheumatic Syndrome Anti-Neoplastic Therapy Raynauds Bleomycin Vinblastine Vincristine Cisplatin Skin thickening Bleomycin Graft-versus-host disease Arthralgias, myalgias Interleukin-2 (post-chemo rheumatism) Aromatase Inhibitors Cisplatin 5-Fluorouracil Cyclophosphamide Methotrexate Tamoxifen SLE-like/RA-like Interferon syndromes Polymyositis Graft-versus-host disease Osteoporosis Aromatase Inhibitors Anti-androgens Reactive Arthritis Bacillus Calmette-Guerin
In the case of bleomycin, there is variability in the schedule of administration, but a dose of 3 mg is typically given 3 times weekly for 5 weeks, followed by once weekly for 10 weeks.
Total wet lung weight was measured as an indicator of lung inflammation due to Bleomycin [7.
With respect to bleomycin specifically, it appears to activate macrophages via one of the toll-like receptors, TLR2.
Alveolar macrophage apoptosis and TNF-alpha, but not p53, expression correlate with murine response to bleomycin.
The detailed dosage regimen used was: bleomycin 15 mg as a 24-hour infusion on days 2 and 3; etoposide 100 mg/[m.
A further 53 patients were randomised to receive both Triomune plus anti-KS chemotherapy consisting of bleomycin, doxorubicin, and vincristine (the ABV regimen).
We describe the use of nitric oxide as an oxygen-sparing strategy in the context of prior bleomycin exposure.
The bulk of the work consists of reviews of the characteristics and uses of the different types of drugs and chemical and biological agents important to the field, including antifolates, cytidine analogues, purine antimetabolites, bleomycin, antitumor antibiotics, asparaginase, bisphosphonates, inhibitors of tumor angiogenesis, interferons, and interleukins, to cite a few.