bleomycin


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Related to bleomycin: cisplatin, doxorubicin

bleomycin

 [ble″o-mi´sin]
an antitumor antibiotic obtained from cultures of Streptomyces verticellus. It binds to DNA and causes single-strand breaks and double-strand scissions, impairing DNA synthesis and inhibiting RNA and protein synthesis. Administered by injection as the sulfate salt to treat lymphomas, soft tissue sarcomas, and cancers of the head and neck, cervix, skin, testes, lung, and other organs.

bleomycin

(blē′ə-mī′sĭn)
n.
Any of a group of antibiotics obtained from the bacterium Streptomyces verticillus. A mixture of them, usually in the form of their sulfate salts, is used as an antineoplastic agent.

bleomycin

(blē′ə-mī′sĭn)
n.
Any of a class of antibiotics isolated from the bacterium Streptomyces verticillus, used usually in sulfate form in combination with other drugs to treat certain kinds of cancer.

bleomycin

A chemotherapeutic antibiotic, which consists of a mixture of low molecular weight (±1.5-kD) metal and oxygen-dependent DNA cleavers, isolated from Streptomyces verticillus, which is used to treat lymphomas, Hodgkin’s disease, Kaposi sarcoma, testicular cancer and other germ cell tumours.
 
Mechanism of action
Induction of single- and double-stranded breaks in DNA.
 
Adverse effects
Fever, stomatitis, skin lesions, marrow suppression, fever, chills and hair loss; fibrosis at > 200 mg/m2 total doses.

bleomycin

Blenoxane, BLEO, BLM Oncology A chemotherapeutic antibiotic, which consists of a mixture of low MW–±1.5 kD metal and oxygen-dependent DNA cleavers, isolated from Streptomyces verticillus verticellus, which is used to treat lymphomas, Hodgkin's disease, Kaposi sarcoma, testicular CA, and other germ cell tumors Mechanism of action Induction of single- and double-stranded breaks in DNA Adverse effects Fever, stomatitis, skin lesions, BM suppression, fever, chills, and hair loss

bleomycin

A toxic glycopeptide antibiotic that interferes with the synthesis of DNA and is used as an anticancer drug, usually in combination with other drugs. It has some value in HODGKIN'S DISEASE, other LYMPHOMAS and squamous cell cancers of the skin. Side effects include FIBROSIS of the lungs, drying and discoloration of the skin over the back of joints. The drug is on the WHO official list.
References in periodicals archive ?
In one study on 50 patients, half were treated with intralesional bleomycin while the rest were given intralesional saline injections.
The authors demonstrated that pirfenidone increased PARK2-mediated mitophagy and attenuated lung fibrosis and oxidative modifications in a bleomycin PARK2 knockout model.
To determine whether FSTL1 has an effect on PF through the MAPK signaling, we first examined the activation of the TGF-[sz]1-mediated MAPK signaling in the lungs of Fstl1 +/− mice and their wild-type (WT) littermates 14 days after bleomycin injury.
Qingfei Xieding given to model groups contributed to the significant decrease of lung collagen content triggered by bleomycin, but it has no adverse influence on that of control groups.
Mice received intratracheal injection of bleomycin in accordance with accepted methods [43].
CS has two settings, either hours after the start of combined CT based on bleomycin, etoposide, and cisplatin (BEP) or much less frequently as an initial presentation of advanced disease with no relation to treatment, as in our patient [4].
Mice were anesthetized with ketamine/xylazine (100mg/kg) and each mouse received 0.05 U of bleomycin sulfate (Bristol-Meyers Pharmaceuticals) dissolved in 50 [micro]l of PBS via oropharyngeal instillation.
We present a 3-year-old boy with a cystic LM in the posterior cervical and supraclavicular triangle, who was treated with two consecutive doses of intralesional bleomycin.
[11] Published treatment guidelines for the management of KS in resource-limited settings include chemotherapy with the single drugs etoposide, thalidomide and vincristine, with two drugs, namely vincristine and bleomycin, and with three drugs, namely doxorubicin (Adriamycin), bleomycin and vinblastine sulphate.
And we had to give our consent for Lauren to receive this drug, called Bleomycin, of creating an onset of another type of cancer is quite high.