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an antitumor antibiotic obtained from cultures of Streptomyces verticellus. It binds to DNA and causes single-strand breaks and double-strand scissions, impairing DNA synthesis and inhibiting RNA and protein synthesis. Administered by injection as the sulfate salt to treat lymphomas, soft tissue sarcomas, and cancers of the head and neck, cervix, skin, testes, lung, and other organs.
Any of a group of antibiotics obtained from the bacterium Streptomyces verticillus. A mixture of them, usually in the form of their sulfate salts, is used as an antineoplastic agent.
Any of a class of antibiotics isolated from the bacterium Streptomyces verticillus, used usually in sulfate form in combination with other drugs to treat certain kinds of cancer.
bleomycinA chemotherapeutic antibiotic, which consists of a mixture of low molecular weight (±1.5-kD) metal and oxygen-dependent DNA cleavers, isolated from Streptomyces verticillus, which is used to treat lymphomas, Hodgkin’s disease, Kaposi sarcoma, testicular cancer and other germ cell tumours.
Mechanism of action
Induction of single- and double-stranded breaks in DNA.
Fever, stomatitis, skin lesions, marrow suppression, fever, chills and hair loss; fibrosis at > 200 mg/m2 total doses.