blastocyst biopsy

blastocyst biopsy

A biopsy performed after the blastocyst differentiates into 2 morphologically distinct cell lines: the trophoblast and the inner cell mass of about 60 cells. Blastocyst-stage biopsy for pre-implantation genetic diagnosis is performed on day three of in vitro culture, which allows the developing TE to protrude after blastulation.
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PGS and mtDNA analysis can be performed in parallel on a single blastocyst biopsy, providing a more thorough picture of embryo health without a significant change in workflow for the clinic or patient.
Cleavage stage embryo biopsy significantly impairs embryonic reproductive potential while blastocyst biopsy does not: a novel paired analysis of cotransferred biopsied and nonbiopsied sibling embryos [ASRM 2011 abstract].
In 2002, Kylie de Boer and her assistants reported the first live birth after blastocyst biopsy for PGD (92).
Blastocyst biopsy has also been suggested in this regard, but since the blastocyst has a higher degree of chromosomal mosaicism and since trophectodermic cells could be mistakenly taken out (they can differ chromosomally from the inner mass cells), Day-3 biopsies prove more accurate (9).
These methods range from biopsy of polar bodies to single-cell blastomere and routine two-cell blastomere biopsy--and, more recently, to blastocyst biopsy.