The differential diagnosis for such large (30-60 mm), spherical structures with single or multiple budding includes P brasiliensis, giant blastoconidia of Candida albicans, and the spherules of Coccidioides immitis.
Giant blastoconidia formation by C albicans can occur after antifungal therapy and can also appear similar to C recurvatus.
Trichosporon species form arthroconidia, blastoconidia
, hyphae, and pseudohyphae.
At these yeast concentrations, many high-power fields contained clusters of blastoconidia and/or hyphal elements.
6] CFU/mL and higher, a large fraction of the examined high-power fields contained Candida, often consisting of clusters of blastoconidia and/or hyphal elements.