Brockes, "Monoclonal antibodies identify
blastemal cells derived from dedifferentiating muscle in newt limb regeneration," Nature, vol.
The
blastemal component is characterized by densely packed oval to spindle undifferentiated cells.
Microscopical picture (hematoxylin-eosin, x100) showing
blastemal cells and stromal element.
Through loss- and gain-of-function approaches, they showed that Fgf signaling emanating from the distal region of the epidermis promotes shh expression in the proximal epidermis but that Fgf/Ras signaling prevents shh expression in the distal epidermis through the induction of pea3 expression and maintenance of wnt5b, an inhibitor of
blastemal proliferation.
In the present study it was shown that the fish treated with a dose of 10 mg.[L.sup.-1] of indomethacin, did not suffer damage on the regenerative process of their tail fins, thus, this dose did not affect the formation of the epidermal cap, connective tissue, blastema,
blastemal cells differentiation and formation of actinotrichia, as well as synthesis, deposition, organisation and mineralisation of the components of the lepidotrichial matrix.
Given its location and its classic small blue cell appearance,
blastemal predominant Wilms tumor should be high on the differential diagnosis.
4.: High power of the edge of the tumour shows osteoid with osteoblasts on the left and mitotically active
blastemal cells at the centre.
value average size (cm) average size (cm) 20 8 cm 4 cm <0.001 Table 3: Histology result Histology Number Pre chemo Post chemo avg size (cm) avg size (cm) Mixed 10 8cm 4cm Necrosis 3 7cm 4cm Epithelial and Stromal 1 8cm 4.5 cm
Blastemal 4 9cm 6cm Anaplastic And other(CMN) 1 8cm 8cm 1
The malignant elements differ from those seen in blastomas in that they lack the
blastemal primitive appearance and histologically resemble adult-type carcinomas and sarcomas.
Immature tissues may include varying amounts of neuroectodermal tissue or
blastemal tissue.
(11) Wilms tumor is a malignant embryonal neoplasm of nephrogenic
blastemal cells.
On microscopy, multiple sections studied from the tumor showed admixture of
blastemal, epithelial and stromal components (Figure 3).
