blast cell


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Related to blast cell: Auer rod, band cell, blast cell leukemia

blast cell

an immature precursor cell; for example, erythroblast, lymphoblast, neuroblast.
See also: -blast.

blast cell

n.
1. A precursor of a human blood cell.
2. An immature, undifferentiated cell.

blast cell

Etymology: Gk, blastos, germ
any immature cell, such as an erythroblast, lymphoblast, or neuroblast.

BLAST

Basic Local Alignment Search Tool. A nucleic acid- and protein-sequence comparison algorithm which is used to find matches in gene sequences and to search sequence databases for optimal local alignments to a query sequence.

BLAST uses a heuristic algorithm, seeking local alignments and creating a matrix of similarity scores for all possible pairs of residues, defining high-scoring segments, statistically evaluating the significance of the results and detecting relationships among sequences which share only isolated regions of similarity.

blast cell

Blast Hematology An immature cell in the BM's proliferative compartment, and earliest identifiable precursor of a cell line–erythroblast, lymphoblast, megakaryoblast and myeloblast; BCs are large–15-20 µm, have high N:C ratios, nuclei with fine, lacy to granular chromatin that contain one or more prominent nucleoli, basophilic, agranular cytoplasm, and abundant RNA, and actively synthesize DNA; BCs represent up to 5% of BM cells

blast cell

(blast sel)
An immature precursor cell; e.g., erythroblast, lymphoblast, neuroblast.
See also: -blast

blast cell

An immature or primitive cell from which mature, differentiated cells are derived. The term refers mainly to the progenitors of blood cells (haemopoietic cells). The presence of these in the circulating blood is a feature of acute leukaemias.
References in periodicals archive ?
No significant co-relation with the amount of circulating blast cells.
The mean percentage of blast cells in the S phase in different heparin concentrations at 0, 1, and 2 h are shown in Table 4.
These experiments evaluated the mechanism of action and activity of elesclomol as a single agent against cell lines representing common genetic aberrations seen in AML as well as primary blast cells from ten AML patients.
Functional p75 interleukin-2 receptor expression on the fresh blast cells in childhood acute lymphoblastic leukemia with natural killer cell properties.
Hematogones may be increased to values of more than 30% of the total cellularity, thus providing a rather alarming morphologic situation, because they may morphologically and phenotypically simulate blast cells of acute lymphoid leukemia.
In more advanced cases of MDS, malignant blast cells dominate the marrow and further inhibit normal marrow function, often giving rise to AML.
Bone marrow aspiration and biopsy demonstrated marked myeloid hyperplasia with maturation and poor granulation of granulocytes, and normal number of blast cells (Figures 1, 2).
Until now there was no evidence that blast cells (hemangioblasts) or their equivalents generated from hESCs possessed the ability to differentiate into smooth muscle cells.
Analysis of surface antigens showed that 49% of cells were blast cells positive for CD7, cytoplasmic CD3 and terminal deoxynucleotidyl transferase (TdT).