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SIRPAA gene on chromosome 20p13 that encodes a ubiquitous immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment, and may play a key role in intracellular signalling during synaptogenesis and in synaptic function. It downregulates receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors and insulin; it also downregulates phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. It is highly expressed in the brain.
Patient discussion about bit
Q. Don’t you feel a bit insincere? I work as a nurse in the ER, and last night a well-known alternative “healer” came to the ER with complaints of bellyache (which turned out to be kidney stones). Now I wouldn’t mind that, except that this healer always speaks against using painkillers and claims that doctors don’t treat the person as a whole like he does. He has no shame to convince patients to avoid hospitals, but when it comes to his own body, he doesn’t seem to believe in his own medications. It’s so frustrating!
my brother is an MD and studied Chinese medicine - he practice both and there is a great advantage in using both to complete the therapy.
Q. if a bee bit me and i am allergic , what would happen to me , and what is the best treatment?
It can be prevented first by avoiding the offending agent, and also by carrying an ready to use adrenalin injector in order to treat it quickly. Also, the allergy can be ameliorated by a series of treatments called immunotherapy, in which the allergic individual is exposed to the allergen in minute amount to make him or her not sensitive any more to this allergen.
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Q. I want to understand why these differences? I'm new to this, and a bit lost... I have indication of mastectomy plus post-mastectomy radiation. I've heard of women in my situation that were prescribed chemo and that's it. No radiation and no breast removal. My doctor said this is not an option for me, but didn't explain anything, although I insisted. I want to understand why these differences? I'm new to this, and a bit lost...