bisphosphonates


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bis·phos·pho·nates

(bis-fos'fō-nāts),
Synthetic pyrophosphate analogues that inhibit osteoclast resorption of bone.

bis·phos·pho·nates

(bis-fos'fŏ-nāts)
Class of medications to treat osteoporosis.

bisphosphonates

A class of drugs that resemble pyrophosphate but are not readily hydrolysed. They interfere with the action of OSTEOCLASTS and thus prevent bone reabsorption in conditions such as PAGET'S DISEASE and OSTEOPOROSIS. They have an established place in the management of metastatic bone secondaries in cancer. The class includes drugs such as clodronate and etidronate (with no nitrogen moiety attached to the central carbon atom side chain), and pamidronate, alendronate, risendronate, ibandronic acid and zoledronic acid, with the nitrogen moiety. The latter group are more potent inhibitors of bone resorption but have more side effects.
References in periodicals archive ?
Research concludes that postmenopausal osteoporotic women taking bisphosphonate drugs exhibited better and increased bone health compared to those not taking bisphosphonates.
Bisphosphonates are derived from naturally occurring inorganic pyrophosphate (PPi).
The Food and Drug Administration (FDA) recommends that patients use bisphosphonates for three to five years, after which they should be reassessed by their clinician.
In addition to the promising signal of a preventive effect for bisphosphonates, her analysis of Osteoarthritis Initiative data yielded two other major findings: Changes over time in the MRI-based three-dimensional bone shape of the knee constitute a novel structural imaging biomarker that appears to be of value in monitoring patients with OA or at high risk for the joint disease, and bisphosphonate-induced suppression of bone turnover had no adverse long-term impact on osteoarthritis risk.
Bisphosphonates and nonhealing femoral fractures: analysis of the FDA Adverse Event Reporting System (FAERS) and international safety efforts: a systematic review from the Research on Adverse Drug Events And Reports (RADAR) project.
It appears that patients and perhaps some clinicians have the mistaken impression that bisphosphonates frequently cause serious adverse effects.
Bandeira, "Atypical femoral fractures during prolonged use of bisphosphonates: short-term responses to strontium ranelate and teriparatide," Journal of Clinical Endocrinology & Metabolism, vol.
The guidelines emphasize the need for reassessment of fracture risks on a regular basis for all women being treated with bisphosphonates for osteoporosis.
BRONJ is the most seen complication (66%) due to bisphosphonates usage.
The vast majority of atypical femur fractures are seen after long-term bisphosphonate use, and many doctors now recommend a five-year limit for taking them, with a periodic assessment of whether the drug is still necessary.
Results showed that there were significant difference of second hip fracture (Pless than 0.05) and mortality (Pless than 0.05) between bisphosphonates group and control group.
Cells were incubated with each of the four alkyl bisphosphonates at a final concentration of 10 mM.