Zymeworks' lead clinical candidate, ZW25, is a novel Azymetric bispecific antibody
currently in Phase 2 clinical development.
On the other hand, bispecific antibody
also shows a promising effect in the field of gene therapy, developed as an adapter molecule to recognize the vector and a specific marker on target cell surface, insuring against modification of the virus and disruption of vector assembly, stability, or activity.
Aptevo Therapeutics announced that it has completed dosing in a single ascending dose, or SAD, Phase 1 study of APVO210, a novel investigational bispecific antibody
candidate being developed for the treatment of autoimmune diseases.
Pandion Therapeutics is a biotechnology company developing bispecific antibody
therapeutics to achieve localized immunomodulation at the site of disease for durable, tissue-specific treatment, while avoiding the systemic immunosuppression of conventional medicines.
M2 EQUITYBITES-April 24, 2019-Innovent treats first patient with advanced malignancy under the Phase I clinical trial of IBI318 bispecific antibody
Global Banking News-April 24, 2019-Innovent treats first patient with advanced malignancy under the Phase I clinical trial of IBI318 bispecific antibody
have restructured their global discovery and development agreement for new immuno-oncology cancer treatments, providing for ongoing collaborative development of two clinical-stage bispecific antibody
They wondered if there was a way to create a bispecific antibody
not from fragments, but from 2 complete half-antibodies.
The new compound will be based on Genmab's bispecific antibody
technology DuoBody and a novel ADC technology from the partner.
They also created a second bispecific antibody
aimed at additional targets.
As a result, when a bispecific antibody
complex binds to healthy tissue away from light, it cannot activate T-cells.