bisoprolol


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Related to bisoprolol: Bisoprolol fumarate

bisoprolol

 [bis″o-pro´lol]
a synthetic beta-adrenergic blocking agent, used as the fumarate salt; administered orally as an antihypertensive agent.

bisoprolol fumarate

Apo-Bisoprolol, Bisoprolol (CA), Cardicor (UK), Emcor (UK), Emcor LS (UK), Monocor (CA), Novo-Bisoprolol (CA), PMS-Bisoprolol (CA), Sandoz Bisoprolol (CA), Zebeta

Pharmacologic class: Beta1-adrenergic blocker

Therapeutic class: Antihypertensive

Pregnancy risk category C

Action

Blocks beta1-adrenergic receptors of sympathetic nervous system in heart and kidney, thereby decreasing myocardial excitability, myocardial oxygen consumption, cardiac output, and renin release from kidney. Also lowers blood pressure without affecting beta2-adrenergic (pulmonary, vascular, and uterine) receptor sites.

Availability

Tablets: 5 mg, 10 mg

Indications and dosages

Hypertension

Adults: Initially, 2.5 to 5 mg P.O. daily. Dosages up to 20 mg P.O. daily have been used.

Dosage adjustment

• Renal or hepatic impairment

Contraindications

• Hypersensitivity to drug

• Sinus bradycardia

• Second- or third-degree heart block

• Cardiogenic shock

• Heart failure

• Children (safety and efficacy not established)

Precautions

Use cautiously in:

• renal or hepatic impairment, pulmonary disease, asthma, diabetes mellitus, thyrotoxicosis, peripheral vascular disease

• patients undergoing anesthesia or major surgery

• elderly patients

• pregnant or breastfeeding patients.

Administration

• Give with or without food, but be consistent to minimize variations in absorption.

• Be aware that drug may be given alone or added to diuretic therapy.

Adverse reactions

CNS: dizziness, depression, paresthesia, sleep disturbances, hallucinations, memory loss, slurred speech

CV: bradycardia, peripheral vascular insufficiency, claudication, hypotension, sinoatrial or atrioventricular (AV) node block, second- or third-degree heart block, heart failure, pulmonary edema, cerebrovascular accident, arrhythmias

EENT: blurred vision, dry eyes, conjunctivitis, tinnitus, rhinitis, pharyngitis

GI: nausea, vomiting, diarrhea, constipation, gastric pain, gastritis, flatulence, anorexia, ischemic colitis, acute pancreatitis, renal and mesenteric arterial thrombosis

GU: dysuria, polyuria, nocturia, erectile dysfunction, Peyronie's disease, decreased libido

Hematologic: eosinophilia, agranulocytosis, thrombocytopenia

Hepatic: hepatomegaly

Metabolic: hyperglycemia, hypoglycemia

Musculoskeletal: arthralgia, muscle cramps

Respiratory: dyspnea, cough, bronchial obstruction, bronchospasm

Skin: rash, purpura, pruritus, dry skin, excessive sweating

Interactions

Drug-drug. Amphetamines, ephedrine, epinephrine, norepinephrine, phenylephrine, pseudoephedrine: unopposed alpha-adrenergic stimulation

Antihypertensives: increased hypotension

Digoxin: additive bradycardia

Dobutamine, dopamine: decrease in beneficial beta1-adrenergic cardiovascular effects

General anesthetics, I.V. phenytoin, verapamil: additive myocardial depression

MAO inhibitors: hypertension (when taken within 14 days of bisoprolol)

Nonsteroidal anti-inflammatory drugs: decreased antihypertensive effect

Thyroid preparations: decreased bisoprolol efficacy

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, blood urea nitrogen, glucose, low-density lipoproteins,

potassium, uric acid: increased levels

Antinuclear antibodies: increased titers

Insulin tolerance test: test interference

Drug-behaviors. Acute alcohol ingestion: additive hypotension

Cocaine use: unopposed alpha-adrenergic stimulation

Patient monitoring

• Closely monitor blood glucose levels in diabetic patients.

• Assess for signs and symptoms of heart failure, including weight gain.

• Stay alert for blood pressure variations. Low blood pressure may indicate overdose.

Patient teaching

• Tell patient to weigh himself daily at same time and to report gain of 3 to 4 lb/day.

• Instruct patient to move slowly when sitting up or standing, to avoid dizziness or light-headedness from blood pressure decrease.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Advise patient to restrict salt intake to help avoid fluid retention.

• Caution patient not to discontinue drug abruptly unless prescriber approves.

• Tell patient to carry medical identification stating that he's taking a beta blocker.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

bisoprolol

(bĭs-ō′prə-lôl′, -lōl′, bĭs′ō-prō′lôl, -lōl)
n.
A beta-blocker drug, C18H31NO4, used in its fumarate form to treat hypertension.

bisoprolol

A selective beta-1-blocker used to manage hypertension and cardiac ischaemia, blocking the G protein and cAMP-signalling cascade, reducing cardiac contractility and heart rate.

Adverse effects
Fatigue, hypotension, hypoglycaemia, bronchospasm, bradycardia.

bisoprolol

A drug used in the treatment of ANGINA PECTORIS and high blood pressure (HYPERTENSION). Brand names are Cardicor, Emcor and Monocor.
References in periodicals archive ?
No significant impact of hematocrit on the quantification was found in the hematocrit range 35-65% for bosentan [70], 38-45% for bosentan and ambrisentan [72], 23-43% for propranolol [65], 41-48% for guanfacine [62], and 20-50% for losartan and losartan carboxylic acid [55] and the hematocrit range of 35-55% for ramipril, lisinopril, valsartan, losartan, diltiazem, doxazosin, bisoprolol, atenolol, simvastatin, and atorvastatin [50].
In addition, a bisoprolol transdermal patch (2 mg) was applied to her chest.
In the present study, throughout the long-term (25[degrees]C/ 60% RH) and accelerated (40[degrees]C/75% RH) stability course of generic bisoprolol film-coated tablets, an increase of a particular degradation product analyzed with HPLC at RRT 0.95 was observed.
The treatment group was treated with bisoprolol fumarate and trimetazidine in addition to treatment for COPD.
A 47 years old female patient presented with history of episodic palpitation 3 years back for which she was managed in Kingdom of Saudi Arabia and was on regular tablet Bisoprolol. She improved symptomatically and for the last 6 months developed progressive exertional dyspnea.
Beta-blockers, like carvedilol, metoprolol, bisoprolol and nebivolol, block the beta-receptors on heart cells, which when stimulated make the heart rate increase.
Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, doubleblind, crossover trial.
An optimized matrix transdermal patch of bisoprolol fumarate was formulated with different concentrations of polysorbate 80 to evaluate the effect of permeation enhancer at different concentration through the excised rabbit's skin.
The substances found were metabolites of cocaine (two findings) and blood-pressure aid bisoprolol. Of the 974 riders breath-tested during the year, none tested positive.
Indeed, on the basis of the drug's performance--a mean reduction in home systolic blood pressure of 8.7 mm Hg, compared with reductions of 4.03 and 4.48 mm Hg for doxazosin and bisoprolol, respectively, in the 314-patient crossover study--no one should any longer be categorized as having treatment-resistant hypertension unless they've first failed to achieve blood pressure control on spironolactone.
Other reported relevant contact allergies were associated with additional beta-blockers (metoprolol, bisoprolol, sotalol hydrochloride), benzodiazepines (alprazolam, lormetazepam, tetrazepam) and angiotensin-converting-enzyme inhibitors (ACE inhibitors) (enalapril, lisonopril, perindopril).