The presence of protoberberine and bisbenzylisoquinoline alkaloids like berberine, oxyberberine, palmatine, oxyacanthine, berbamine, and tetrandrine are mainly responsible for the diverse pharmacological properties of the genus [4, 5].
The current study deals with the chromatographic isolation and spectroscopic characterization of bisbenzylisoquinoline alkaloids 1 and 2 followed by their urease inhibitory effect in vitro.
Schiff, "Bisbenzylisoquinoline alkaloids," Journal of Natural Products, vol.
Two new bisbenzylisoquinoline alkaloids, (+)-cocsoline 2'-[beta]-Noxide (49), and (+)-12-0-methylcocsoline 2'-[beta]-N-oxide (50), were isolated from polar fractions of the roots of Anisocycla cymosa, in addition to eight known bisbenzylisoquinoline, aporphine, protoberberine, and phenanthrene alkaloids (Kanyinda et al.
Cycleanine N-oxide (51) was isolated from the stems of Synclisia scabrida, along with the known bisbenzylisoquinoline alkaloids cycleanine, norcycleanine, cocsuline, and cocsoline (Ohiri et al.
Some bisbenzylisoquinoline alkaloids (tetrandrine and berbamine) inhibited neutrophil adhesion and locomotion [45, 46].
Warifteine, a bisbenzylisoquinoline alkaloid, is the major alkaloid purified from both root and leaves of C.
(29) A P450 corytuberine synthase (CYP80G2; EC 1.14.21.-) was found to have a significant level of amino acid sequence similarity to that of berbamu nine synthase (CYP80A1; EC 126.96.36.199) in the biosynthesis of bisbenzylisoquinoline alkaloids
via a C-O phenol-coupling reaction.
Tetrandrine and fangchinoline are bisbenzylisoquinoline alkaloids
, occurring in roots of the creeper Stephania tetrandra Moore (Wu et al.
Keywords: Nelumbo nucifera; Bisbenzylisoquinoline alkaloids
; Neferine; Sedation; Behavior; Central nervous system
In vitro activity of Triclisia patents and some bisbenzylisoquinoline alkaloids
against Leishmania donovani and Trypanosoma brucei brucei.