Two new bisbenzylisoquinoline alkaloids, (+)-cocsoline 2'-[beta]-Noxide (49), and (+)-12-0-methylcocsoline 2'-[beta]-N-oxide (50), were isolated from polar fractions of the roots of Anisocycla cymosa, in addition to eight known bisbenzylisoquinoline, aporphine, protoberberine, and phenanthrene alkaloids (Kanyinda et al.
Cycleanine N-oxide (51) was isolated from the stems of Synclisia scabrida, along with the known bisbenzylisoquinoline alkaloids cycleanine, norcycleanine, cocsuline, and cocsoline (Ohiri et al.
Investigation on Cocculus pendulus (Menispermaceae) resulted in the isolation of two new alkaloids, kurramine 2'-[beta]-N-oxide (55) and kurramine 2'-[alpha]-N-oxide (56), and three known bisbenzylisoquinoline alkaloids (Rahman et al.
3) in the biosynthesis of bisbenzylisoquinoline alkaloids
via a C-O phenol-coupling reaction.
japonica contains isotrilobine and trilobine, bisbenzylisoquinoline alkaloids
, which was previously reported to possess multidrug-resistance-reversing activity in human breast cancer cell line .
Trypanocidal bisbenzylisoquinoline alkaloids are inhibitors of trypanothione reductase.
Efficacy of the bisbenzylisoquinoline alkaloids in acute and chronic Trypanosoma cruzi murine model.
Tetrandrine and fangchinoline are bisbenzylisoquinoline alkaloids, occurring in roots of the creeper Stephania tetrandra Moore (Wu et al.
In summary, this study demonstrates that the bisbenzylisoquinoline alkaloids tetrandrine and fangchinoline can reverse P-gp mediated MDR and P-gp activity (both protein expression and efflux activity), and may serve as promising MDR reversal agents and potential adjuvants for cancer therapy themselves or serve as leads for the development of more powerful semisynthetic derivatives.
A previous study reported that bisbenzylisoquinoline alkaloids, such as neferine and liensinine, were isolated from this plant (Furukawa, 1966); however, the central effects of the embryo of the seeds of Nelumbo nucifera have not been characterized.
A previous report demonstrated that bisbenzylisoquinoline alkaloids, such as neferine and liensinine, were isolated from this plant (Furukawa, 1966), which is in agreement with the results of this study.
In vitro activity of Triclisia patents and some bisbenzylisoquinoline alkaloids
against Leishmania donovani and Trypanosoma brucei brucei.