The albumin peak is split; this phenomenon is known as bisalbuminemia or alloalbuminemia.
Bisalbuminemia is usually caused by an albumin variant that differs from the most common allotype, albumin A, by a single amino acid residue, thereby producing 2 albumin fractions of equal or unequal amounts.
This pattern could potentially be confused with bisalbuminemia
, an uncommon inherited condition in which 2 albumin allelic variants have different migrational properties.
(or alloalbuminemia) is a rare inherited or acquired condition characterized by the occurrence of 2 circulating components that are observed, typically, during routine clinical electrophoresis or in genetic surveys.
Improved sensitivity of capillary electrophoresis for detection of bisalbuminemia. Clin Chem 2000;46:882-3.
Inherited bisalbuminemia with benign monoclonal gammopathy detected by capillary but not agarose gel electrophoresis.
Bisalbuminemia (or alloalbuminemia) is characterized by the presence of two albumin components (in equal or unequal amounts) on serum protein electrophoresis (1).
We recently encountered a patient with both bisalbuminemia and monoclonal paraprotein.
Whereas genetic variants of Alb apparently lack clinical relevance (27), one form of bisalbuminemia
caused by abnormal cleavage of the Alb propeptide in cases of pancreatic disease mimics anodal bisalbuminemia
(28) and would be detectable by these algorithms.
Improved sensitivity of capillary zone electrophoresis for detection of bisalbuminemia
We wish to report our findings on bisalbuminemia
detected by capillary electrophoresis.
Albumin is probably the most commonly measured serum protein, and genetic variation, or bisalbuminemia
, is usually detected by electrophoresis of plasma collected for diagnostic reasons.