biphosphonate

Endocrinology Any of a number of carbon-substituted analogues of pyrophosphate, an endogenous inhibitor of bone mineralization Indications Malignant hypercalcemia, Paget's disease, breast and prostate CA, myeloma; the most potent is zoledronic acid, which can be given at intervals of up to one yr Adverse events Oral–GI intolerance; IV–myalgia, pyrexia. See Osteoporosis.

References in periodicals archive ?

Biphosphonate therapy for reduced bone mineral density during treatment of acute lymphoblastic leukemia in childhood and adolescence.

Bone Loss in Pediatric Survivors of Acute Lymphoblastic Leukemia

Therefore, to bring the hypercalcemia under control, treatments were applied of hydration, subcutaneous calcitonin, and parenteral biphosphonate (Zoledronic acid: Zometa[R] ampoule Novartis, Stein, Switzerland).

An unusual cause of hypercalcemic crisis: Water-clear cell double parathyroid adenoma

Fortunately neither has ruled out suitable exercise, so with veterinary support, local injection steroids, systemic biphosphonate and careful management, the 11-year-old gelding continues to enjoy an active life with lunging and schooling to keep him supple.

Only Paddy displays genuine endurance

This has been seen in a patient undergoing chemotherapy or biphosphonate treatment including reduction of some of the undesirable side effects of the treatments (33).

Cancer in North Cyprus: 1. Current Status, An Overview

The surface of the above prepared hydroxyapatite was modified using a biphosphonate compound i.e.

Surface Modification of Nano-Hydroxyapatite Using Bisphosphonate Moieties: Effect on Morphology and Crystalline Nature at Higher Temperature

The patient had chronic medical conditions that favored a parenteral therapy over an oral biphosphonate. As with all drugs, the clinician's decision to prescribe must be based on careful assessment of the benefits and risks for the individual patient.

Stroke following zoledronic acid infusion: effect of treatment or coincidence?/Zoledronik asit infuzyonu sonrasi gelisen inme: Tedavinin yan etkisi mi tesaduf mu?

In 2003, Marx first identified osteonecrosis of the jaw associated with biphosphonate therapy.

Bisphosphonate-related osteonecrosis of the jaw

This is another biphosphonate that has been approved by the FDA for prevention and treatment of osteoporosis in postmenopausal women.

Osteoporosis

(1) Zoledronic acid (aclasta) is an annual biphosphonate IV infusion given over 15-30 minutes.

Primary health care nurses take on new challenges: opportunities for innovation in primary care are increasing. Nurses at one North Island practice are now delivering aclasta infusions, a procedure traditionally performed in hospitals

They were also given a sodium biphosphonate enema to be used the morning of the procedure to ensure adequate bowel preparation.

A prospective study on pain score with transperineal prostatic gold seed fiducial implantation under local anesthetic alone

Hashimoto et al., "Successful treatment of MMP9-expressing angiosarcoma with low-dose docetaxel and biphosphonate," Case Reports in Dermatology, vol.

Potential use of bisphosphonates in invasive extramammary paget's disease: an immunohistochemical investigation

(2005) examined the long-term effects of WBV on osteoporotic women who received alendronate, a biphosphonate drug used for osteoporosis.

Whole-body vibration and rehabilitation of chronic diseases: a review of the literature