biphosphonate

biphosphonate

Endocrinology Any of a number of carbon-substituted analogues of pyrophosphate, an endogenous inhibitor of bone mineralization Indications Malignant hypercalcemia, Paget's disease, breast and prostate CA, myeloma; the most potent is zoledronic acid, which can be given at intervals of up to one yr Adverse events Oral–GI intolerance; IV–myalgia, pyrexia. See Osteoporosis.
References in periodicals archive ?
Biphosphonate therapy for reduced bone mineral density during treatment of acute lymphoblastic leukemia in childhood and adolescence.
Therefore, to bring the hypercalcemia under control, treatments were applied of hydration, subcutaneous calcitonin, and parenteral biphosphonate (Zoledronic acid: Zometa[R] ampoule Novartis, Stein, Switzerland).
Fortunately neither has ruled out suitable exercise, so with veterinary support, local injection steroids, systemic biphosphonate and careful management, the 11-year-old gelding continues to enjoy an active life with lunging and schooling to keep him supple.
This has been seen in a patient undergoing chemotherapy or biphosphonate treatment including reduction of some of the undesirable side effects of the treatments (33).
The surface of the above prepared hydroxyapatite was modified using a biphosphonate compound i.e.
The patient had chronic medical conditions that favored a parenteral therapy over an oral biphosphonate. As with all drugs, the clinician's decision to prescribe must be based on careful assessment of the benefits and risks for the individual patient.
In 2003, Marx first identified osteonecrosis of the jaw associated with biphosphonate therapy.
This is another biphosphonate that has been approved by the FDA for prevention and treatment of osteoporosis in postmenopausal women.
They were also given a sodium biphosphonate enema to be used the morning of the procedure to ensure adequate bowel preparation.
Hashimoto et al., "Successful treatment of MMP9-expressing angiosarcoma with low-dose docetaxel and biphosphonate," Case Reports in Dermatology, vol.
(2005) examined the long-term effects of WBV on osteoporotic women who received alendronate, a biphosphonate drug used for osteoporosis.