biphosphonate

biphosphonate

Endocrinology Any of a number of carbon-substituted analogues of pyrophosphate, an endogenous inhibitor of bone mineralization Indications Malignant hypercalcemia, Paget's disease, breast and prostate CA, myeloma; the most potent is zoledronic acid, which can be given at intervals of up to one yr Adverse events Oral–GI intolerance; IV–myalgia, pyrexia. See Osteoporosis.
References in periodicals archive ?
Fortunately neither has ruled out suitable exercise, so with veterinary support, local injection steroids, systemic biphosphonate and careful management, the 11-year-old gelding continues to enjoy an active life with lunging and schooling to keep him supple.
This has been seen in a patient undergoing chemotherapy or biphosphonate treatment including reduction of some of the undesirable side effects of the treatments (33).
In 2003, Marx first identified osteonecrosis of the jaw associated with biphosphonate therapy.
This is another biphosphonate that has been approved by the FDA for prevention and treatment of osteoporosis in postmenopausal women.
They were also given a sodium biphosphonate enema to be used the morning of the procedure to ensure adequate bowel preparation.
2005) examined the long-term effects of WBV on osteoporotic women who received alendronate, a biphosphonate drug used for osteoporosis.
It has been shown recently that a biphosphonate incorporated on to titanium implants increased bone density locally in the peri-implant region.
For example, 'disease mongering' - Osteopenia, once considered a non-disease state in patients who had not lost enough bone density to be diagnosed with osteoporosis, has now turned into a disease itself, tryin gto convince physicians and patients that biphosphonate drug treatment will prevent their 'disease' from progressing.
Biphosphonate incadronate inhibits growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells by interfering with the mevalonate pathway.