This is sometimes referred as a biphasic response
. Our results at higher dose of BPA are contradictory to the findings of Mandich et al.
The addition of [Gd.sup.3+] did not affect the time course of the biphasic response
. [Gd.sup.3+] did not alter the interspike interval significantly (n = 8 fibers; p > 0.05, two-sample paired Student's t-test); although the amplitude of the [Ca.sup.2+] signal was reduced after the [Gd.sup.3+] addition, this effect was not further evaluated.
We observed a biphasic response
where physiological (low) doses of [beta]-estradiol induce cell growth and cellular proliferation of Jurkat T -cells, whereas higher doses inhibit cell growth and induce cell death.
(6,17) Hypoxia is reported to elicit a sustained monophasic rise in PAP in vivo, and a biphasic response
in the isolated pulmonary artery and isolated perfused lung.
Insulin activates Na(+)/H(+) exchanger 3: biphasic response
and glucocorticoid dependence.
This might be due to the inhibition of the biphasic response
induced by the carrageenan.
Heart rate turbulence is the biphasic response
of the sinus node to premature ventricular contractions.
Fluid shear stress induces a biphasic response
of human monocyte chemotactic protein-1 gene expression in vascular endothelium.
Continuous peripancreatic venous sampling after glucose challenge provides an accurate temporal profile of zinc release, whereby the biphasic response
could be assessed.
The authors speculate that these effects may indicate a biphasic response
to PBDE-99, and suggest that the phenomenon should be studied further in future research.
In one preparation, stimulation at point A produced a biphasic response
in the muscle fibers of the ipsilateral valve [ILLUSTRATION FOR FIGURE 4C OMITTED]; in five others, stimulation at point B produced biphasic responses
This biphasic response
correlates with how genistein is thought to exert its effects.