The main finding of this study was the observation of a biphasic response by pulmonary vasculature to sustained hypoxic ventilation in the presence of PHE, an [[alpha].
6,17) Hypoxia is reported to elicit a sustained monophasic rise in PAP in vivo, and a biphasic response in the isolated pulmonary artery and isolated perfused lung.
Heart rate turbulence is the biphasic response
of the sinus node to premature ventricular contractions.
Fluid shear stress induces a biphasic response
of human monocyte chemotactic protein-1 gene expression in vascular endothelium.
The authors speculate that these effects may indicate a biphasic response
to PBDE-99, and suggest that the phenomenon should be studied further in future research.
In one preparation, stimulation at point A produced a biphasic response in the muscle fibers of the ipsilateral valve [ILLUSTRATION FOR FIGURE 4C OMITTED]; in five others, stimulation at point B produced biphasic responses.
Biphasic responses were not apparent in recordings of LAA flow and DAA pressure, where only the effects of valve contraction were apparent.
This biphasic response
correlates with how genistein is thought to exert its effects.
It is possible that BzATP only affected the second component of the biphasic response
In contrast, time-course studies showed that cells exposed to the high concentration of MCE (125 [micro]g lyophilized cells/mL) exhibited a biphasic response
in their intracellular GSH.
In vivo studies with rodents also support the notion that BPA produce non-monotonic, biphasic responses
(Xu et al.
3] resulted in significantly biphasic responses
in ANN (Figure 3B) and LnRMSSD (Figure 3H), which increased in the first 24 hr and decreased in the last 24 hr.