biphasic pulmonary blastoma

biphasic pulmonary blastoma

A rare malignant tumour of the lungs which affects adults, average age 43, and is linked to tobacco use.

Clinical findings
Asymptomatic to symptoms of nonspecific lung disease.

Imaging
Usually a large peripheral nodule.

Management
Surgical excision.

Prognosis
Poor; 16% 5-year survival.

Poor prognosticators
Tumour recurrence, metastasis at presentation, tumour > 5 cm, nodal metastasis.
References in periodicals archive ?
The prognosis of patients with FA as a whole is considered to be better than that of most other forms of non-small cell carcinoma, including biphasic pulmonary blastoma. According to the previous study, the 10 year survival for WDFA is about 75% versus about 15% for BPB (12, 13) .
(4,24,26) Recurrence occurs in approximately 43% of biphasic pulmonary blastomas. The prognosis for patients with biphasic blastomas is poor.8,26 Survival is 33% at 2 years, 16% at 5 years, and 8% at 10 years.26 Patients with stage I "blastomas" have a 5-year survival rate of about 25%.
Biphasic pulmonary blastomas have both a malignant glandular component and an embryonic or "blastematous" stroma (2,4) (Figure 7).