biosafety level

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Related to biosafety level 4: biosafety level 2

biosafety level

(1) The degree of caution required when working with specific groups of pathogens
(2) A specific combination of work practices, safety equipment, and facilities, intended to minimise exposure of workers and environment to certain classes of pathogens.

Biosafety level 
BL 1—Organisms are relatively innocuous and are not known to cause infection in healthy human adult—e.g., Bacillus subtilis and Naegleria gruberi.
 
BL 21—Organisms are “moderate risk” agents that may cause human disease of varying severity, potentially affecting healthy adults; often good microbiologic technique, such as minimising exposure to aerosols, is a sufficient precaution for these agents—e.g., C difficile, hepatitis A, B and C, influenza A, Lyme disease, dengue fever, Salmonella; mumps, measles, HIV, scrapie, MRSA and VRSA. 

BL 32—Organisms are indigenous or exotic and may infect personnel by aerosols, autoinoculation or ingestion, resulting in potentially serious or lethal consequences—e.g., Mycobacterium tuberculosis, Bacillus anthracis, West Nile virus, Venezuelan equine encephalitis virus, Eastern equine encephalitis virus, Hendra virus, SARS coronavirus, Salmonella typhi, Coxiella burnetii, Rift Valley fever virus, Rickettsia rickettsii and yellow fever virus.
 
BL 4—Organisms are dangerous and exotic, require a maximum containment facility and pose a high individual risk of exposure and risk to laboratory personnel—e.g., Bolivian and Argentine hemorrhagic fevers, Marburg virus, Ebola virus, Lassa fever, Crimean-Congo hemorrhagic fever and other various hemorrhagic diseases. BSL 4 agents may be transmitted by aerosol; there is no vaccine or therapy.

biosafety level

Epidemiology A classification for the degree of caution required when working with specific groups of pathogens. See Maximum containment facility.

biosafety level

(bī″ō-sāf′tē),

BSL

A classification system to indicate the safety precautions required when investigating microorganisms, esp. viruses known to be dangerous or lethal to those exposed to them. There are four BSLs, with BSL-4 requiring the highest level of security.
References in periodicals archive ?
(15) The Biosafety Level 4 (BSL-4) is required for work with dangerous and exotic agents that pose a high risk of life threatening disease.
Potential impact of a 2-person security rule on Biosafety Level 4 laboratory workers.
These national labs, Los Alamos and Lawrence Livermore (Oak Ridge National Lab in Tennessee is considering building a biosafety Level 4 facility), have a mission to provide the Pentagon with deliverable nuclear weapons with researchers working in highly compartmentalized and secretive environments.
The threat of terrorists using as weapons the most deadly pathogens known, coupled with the recognition that virtually every year a new infectious disease is discovered, has led the US government to expand the number of Biosafety Level 4 (BSL-4) laboratories, also known as maximum containment laboratories (MCLs), to perform work essential for promoting public health and to ensure bioterrorism preparedness.
Bioterrorism agents used can be categorized as biosafety level 2 pathogens such as salmonella, biosafety level 3 pathogens such as Venezuelan equine encephalitis, or biosafety level 4 pathogens such as smallpox (see Table 2).
Invitation to tender : The Institute of Virology and Immunology (IVI) is the Swiss reference laboratory (Biosafety Level 4) for diagnosis, monitoring and control of highly contagious animal diseases, such as avian influenza (bird flu), foot and mouth disease and classical swine fever.
Culture of B virus requires a special containment facility since the virus is a biosafety level 4 pathogen (31).
Objectives with mid to long-term impact are: (i) Provide information on pathophysiological changes and immunological determinants to infer new immunotherapeutic strategies for treatment of EVD; and (ii) Strengthening cooperation of biosafety level 4 (BSL-4) facilities and building a pan-European research area in the field of highly pathogenic viruses as envisaged in the European Research Infrastructure on Highly Pathogenic Agents project.
Virus isolation attempts were then terminated because the cultivation of C-CHFV (the presumptive cause) requires biosafety level 4 facilities.
Tenders are invited for Biosafety Level 4 (BSL4) Laboratory Consultant
These viruses are extremely hazardous and must be handled under strict Biosafety Level 4 containment.
All work with live variola virus is done under biosafety level 4 containment conditions at CDC.