biosafety level

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biosafety level

(1) The degree of caution required when working with specific groups of pathogens
(2) A specific combination of work practices, safety equipment, and facilities, intended to minimise exposure of workers and environment to certain classes of pathogens.

Biosafety level 
BL 1—Organisms are relatively innocuous and are not known to cause infection in healthy human adult—e.g., Bacillus subtilis and Naegleria gruberi.
 
BL 21—Organisms are “moderate risk” agents that may cause human disease of varying severity, potentially affecting healthy adults; often good microbiologic technique, such as minimising exposure to aerosols, is a sufficient precaution for these agents—e.g., C difficile, hepatitis A, B and C, influenza A, Lyme disease, dengue fever, Salmonella; mumps, measles, HIV, scrapie, MRSA and VRSA. 

BL 32—Organisms are indigenous or exotic and may infect personnel by aerosols, autoinoculation or ingestion, resulting in potentially serious or lethal consequences—e.g., Mycobacterium tuberculosis, Bacillus anthracis, West Nile virus, Venezuelan equine encephalitis virus, Eastern equine encephalitis virus, Hendra virus, SARS coronavirus, Salmonella typhi, Coxiella burnetii, Rift Valley fever virus, Rickettsia rickettsii and yellow fever virus.
 
BL 4—Organisms are dangerous and exotic, require a maximum containment facility and pose a high individual risk of exposure and risk to laboratory personnel—e.g., Bolivian and Argentine hemorrhagic fevers, Marburg virus, Ebola virus, Lassa fever, Crimean-Congo hemorrhagic fever and other various hemorrhagic diseases. BSL 4 agents may be transmitted by aerosol; there is no vaccine or therapy.

biosafety level

Epidemiology A classification for the degree of caution required when working with specific groups of pathogens. See Maximum containment facility.

biosafety level

(bī″ō-sāf′tē),

BSL

A classification system to indicate the safety precautions required when investigating microorganisms, esp. viruses known to be dangerous or lethal to those exposed to them. There are four BSLs, with BSL-4 requiring the highest level of security.
References in periodicals archive ?
Biosafety Level 3 applies to agents that may be transmitted by the respiratory route and can cause serious infection.
The University of Wyoming (UW) requests your response of qualifications to provide Commissioning Authority services for a project known as: Wyoming State Veterinary Laboratory, Biosafety Level 3 Lab Renovation (abbv.
The WSVL BSL-3 Lab has not been able to be utilized for its intended function and use as a certified Biosafety Level 3 laboratory working with select agents.
Bioterrorism agents used can be categorized as biosafety level 2 pathogens such as salmonella, biosafety level 3 pathogens such as Venezuelan equine encephalitis, or biosafety level 4 pathogens such as smallpox (see Table 2).
Level D labs would be responsible for developing new rapid identification tests for bioterrorism agents, testing all agents for chimeras (genetically altered organism that may not be detectable by current methods), and for culturing and performing antimicrobial susceptibility tests on all biosafety level 3 and 4 bioterrorism agents.
The high case-fatality ratio of HCPS (40%), coupled with its airborne transmission by captive rodents, has led to classification of the agents of HCPS as biosafety level 3 (BSL-3) in tissue culture and BSL-4 in reservoir host rodents.
Under the new guidelines from CDC, these procedures must be performed only in Biosafety Level 3 facilities.
In fact, we are expanding our biosafety level 3 facility to accommodate certain aspects the new work.
Acquisition and installation of two steam sterilizers was under the management of the laundry and laboratory containment biosafety level 3 building INSERM Jean Bernard Hospital Saint Louis University Paris Diderot - Paris 7.
The Company is seeking additional equity financing to enhance its bio-defense capabilities with regard to expanding and upgrading its accredited biosafety level 3 laboratory suite.
Calypte's Rockville facility holds a biological license approval from the FDA and manufactures the company's HIV-1 Western Blot tests and houses a Biosafety Level 3 laboratory for the production of HIV-1 viral materials.
The first TB research institute located within a College of Pharmacy, the new biosafety level 3 (BSL-3) lab is dedicated solely to testing and developing efficacious therapies for people afflicted with tuberculosis, the world's leading bacterial killer.