biosafety level


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biosafety level

(1) The degree of caution required when working with specific groups of pathogens
(2) A specific combination of work practices, safety equipment, and facilities, intended to minimise exposure of workers and environment to certain classes of pathogens.

Biosafety level 
BL 1—Organisms are relatively innocuous and are not known to cause infection in healthy human adult—e.g., Bacillus subtilis and Naegleria gruberi.
 
BL 21—Organisms are “moderate risk” agents that may cause human disease of varying severity, potentially affecting healthy adults; often good microbiologic technique, such as minimising exposure to aerosols, is a sufficient precaution for these agents—e.g., C difficile, hepatitis A, B and C, influenza A, Lyme disease, dengue fever, Salmonella; mumps, measles, HIV, scrapie, MRSA and VRSA. 

BL 32—Organisms are indigenous or exotic and may infect personnel by aerosols, autoinoculation or ingestion, resulting in potentially serious or lethal consequences—e.g., Mycobacterium tuberculosis, Bacillus anthracis, West Nile virus, Venezuelan equine encephalitis virus, Eastern equine encephalitis virus, Hendra virus, SARS coronavirus, Salmonella typhi, Coxiella burnetii, Rift Valley fever virus, Rickettsia rickettsii and yellow fever virus.
 
BL 4—Organisms are dangerous and exotic, require a maximum containment facility and pose a high individual risk of exposure and risk to laboratory personnel—e.g., Bolivian and Argentine hemorrhagic fevers, Marburg virus, Ebola virus, Lassa fever, Crimean-Congo hemorrhagic fever and other various hemorrhagic diseases. BSL 4 agents may be transmitted by aerosol; there is no vaccine or therapy.

biosafety level

Epidemiology A classification for the degree of caution required when working with specific groups of pathogens. See Maximum containment facility.

biosafety level

(bī″ō-sāf′tē),

BSL

A classification system to indicate the safety precautions required when investigating microorganisms, esp. viruses known to be dangerous or lethal to those exposed to them. There are four BSLs, with BSL-4 requiring the highest level of security.
References in periodicals archive ?
The first limitation is that all of these procedures require that the transfer of plasma into the second tube and the inactivation procedure be performed by trained personnel in a biosafety level 2 safety cabinet under rigorous safety practices.
The security of Biosafety Level 3 and 4 facilities is also a concern.
For instance, a tuberculosis laboratory at a hospital is categorized as a biosafety Level 3 laboratory, officials explained.
The Purifier Class I Safety Enclosures provide user protection from agents that require Biosafety level 1, 2, or 3 containment.
Los Alamos is in the process of raising the walls for a biological safety Level 3 facility that will house two biosafety Level 3 labs and one biosafety Level 2 lab.
The Purifier Delta Series Class II, Type B2 Total Exhaust Safety Cabinets provide personnel, product and environmental protection and are suitable for work with agents that require Biosafety level 1, 2 or 3 containment.
Core research facilities at the campus center include electron microscopes, nuclear magnetic resonance devices, mass spectrometers, x-ray crystallography, a sequencing center, and BioSafety Level 1, 2, 3 labs (BSL-4, the highest containment level labs are not on-site).
Design and use of allocated work space to meet all applicable requirements for design and safety: Is the proper Biosafety Level workspace provided?
Currently, all operational biosafety level (BSL) 4 labs are registered with the CDC and thus are regulated by the CDC, not USDA.
In addition, CDC changed lines of authority and responsibility to ensure impartial and credible oversight, including moving oversight for the animal care and use program to the Office of the Director, putting it on equal standing with oversight for human subjects research, and assigning three veterinarians and two animal caretakers with independent access to the agency's Biosafety Level 4 laboratory.
Tests for neutralizing antibody to this virus require handling live virus under biosafety level 2 containment and thus are only available by special request at CDC (through state health departments) and selected reference laboratories.
The Purifier Delta Series Safety Cabinets provide personnel, product, and environmental protection, and are suitable for work with agents that require biosafety level one, two, or three containment.