biotin

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biotin

 [bi´o-tin]
a sulfur-containing member of the vitamin B complex that plays an essential role in gluconeogenesis and the synthesis of fatty acids. Food sources include liver, egg yolk, soy flour, cereals, and yeast. For recommended daily intake, see Section 4 of the appendices. See also vitamin.

bi·o·tin

(bī'ō-tin),
The d-isomer component of the vitamin B2 complex occurring in or required by most organisms and inactivated by avidin; participates in biologic carboxylations. It is a small molecule with a high affinity for avidin that can be readily coupled to a previously labeled antibody to allow visualization by enzymatic or histochemical means.
See also: avidin.

biotin

(bī′ə-tĭn)
n.
A vitamin, C10H16N2O3S, that is a component of the vitamin B complex and is a cofactor in many enzyme systems. It is found in large quantities in liver, egg yolk, milk, and yeast and is used in many biotechnology applications.

biotin

A water-soluble B vitamin.

Biochemistry
Biotin is the d-isomer of vitamin-B2 complex, which is a prosthetic group for carboxylase enzymes and important in fatty acid biosynthesis and catabolism. It is present in and essential for most animals, as it participates in carboxylation; daily requirements are in the mg range; biotin deficiency is rare.
 
Lab medicine
Biotin is widely used as a covalent label for macromolecules which are detected by high-affinity binding of labelled avidin or streptavidin.

Molecular biology
Biotin can be incorporated into dUTP and used as a non-radioactive label for a DNA probe. It is used to label nucleic acids and proteins that may be subsequently detected by avidin or streptavidin linked to a fluorescent or enzymatic reporter molecule.

bi·o·tin

(bī'ō-tin)
The d-isomer component of the vitamin B2 complex occurring in or required by most organisms and inactivated by avidin; participates in biologic carboxylations.

biotin

A water-soluble B vitamin concerned in the metabolism of fats and carbohydrates. Deficiency causes DERMATITIS, muscle pain, loss of appetite and ANAEMIA.

biotin

a water-soluble vitamin of the B-COMPLEX present in many foods, including yeast, liver and fresh vegetables. Biotin acts as a COENZYME in amino acid and lipid METABOLISM. A deficiency (rare in humans) of biotin causes dermatitis and intestinal problems.

bi·o·tin

(bī'ō-tin)
The d-isomer component of the vitamin B2 complex occurring in or required by most organisms and inactivated by avidin.
See also: avidin