biomarker

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marker

 [mahr´ker]
something that identifies or that is used to identify; see also determinant.
cell-surface marker an antigenic determinant found on the surface of a specific type of cell.
tumor marker a biochemical substance indicative of presence of a tumor; ideally, it should be specific, sensitive, and proportional to tumor load. Called also biomarker.

biomarker

(bī-ō-mark'ĕr),
A detectable cellular or molecular indicator of exposure, health effects, or susceptibility, which can be used to measure the absorbed, metabolized, or biologically effective dose of a substance, the response to the substance including susceptibility and resistance, idiosyncratic reactions, and other factors or conditions.

biomarker

/bio·mark·er/ (bi´o-mahr″ker)
1. a biological molecule used as a marker for a substance or process of interest.

biomarker

(bī′ō-mär′kər)
n.
1. Medicine
a. A physiological substance, such as human chorionic gonadotropin or alpha-fetoprotein, that when present in abnormal amounts in the serum may indicate the presence of disease, as that caused by a malignancy.
b. A specific physical trait used to measure or indicate the effects or progress of a disease or condition: Biomarkers of aging include thinning of the hair. Also called biosignature.

biomarker

(1) A characteristic which is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or pharmacologic responses to a therapeutic intervention.
(2) A molecular indicator of a specific biological property or function that can be measured in blood or other body fluids or tissues; a biochemical feature or facet that can be used to suggest the presence of a particular disease, measure its progress or the effects of treatment.
 
Examples
PSA for prostate cancer, Hb1a for glucose control in diabetics, troponin I for acute MI.

biomarker

Diagnostic medicine Any relatively specific biochemical parameter–eg, PSA, Hb1a or troponin I which, when found in ↑ amount in the blood, other body fluids, or tissues, suggest the presence of certain diseases or cancers. See Cardiac marker, Tumor marker.

bi·o·mark·er

(bīō-mahr-kĕr)
A detectable cellular or molecular indicator of exposure,health effects, or susceptibility, which can be used to measure the absorbed, metabolized, or biologically effective dose of a substance, the response to the substance including susceptibility and resistance, idiosyncratic reactions, and other factors or conditions.

Biomarker

A biochemical substance that can be detected in blood samples and indicates the presence of a cancerous tumor.
Mentioned in: Ovarian Cancer

bi·o·mark·er

(bīō-mahr-kĕr)
A detectable cellular or molecular indicator of exposure, health effects, or susceptibility, which can be used to measure the absorbed, metabolized, or biologically effective dose of a substance, the response to the substance including susceptibility and resistance, idiosyncratic reactions, and other factors or conditions.

biomarker,

n a short-lived radioactive molecule that can be used as a marker to follow a condition or a process.

biomarker

a biological unit used as an indirect indicator of the impact of pollutants on biota, e.g. an enzyme such as mixed function oxygenase levels, immune status of animals in the receiving environment.

Patient discussion about biomarker

Q. what is a safe tumor marker number range?

A. depends on the marker...most of the markers are materials that found normally in our body. and there are a number of markers and their levels differentiate. what marker do you mean?

Q. My wife(53) has elevated CEA and CA19.9 levels - near 150, without any concomitant reason/observation? Comment

A. Hi Bobby3,

The most important question is why were these tests done?
An elevated level may result from many causes, some of them are simple and some are more problematic. IMHO the best thing would be consulting her doctor to consider the need to check-up her alimentary system.
You can read more here (http://www.ascocancerfoundation.org/patient/ASCO+Resources/Patient+Guides/ASCO+Patient+Guide:+Tumor+Markers+for+Gastrointestinal+Cancers) and here (http://www.cancer.gov/cancertopics/factsheet/Detection/tumor-markers)

More discussions about biomarker
References in periodicals archive ?
Biomarkers play a role in use of pharmacogenetics, pharmacogenomics and pharmacoproteomics for development of personalized medicine.
Because errors in DNA methylation accumulate with age at a far greater rate than errors in the DNA sequence, it is a major factor in the presence of disease such as cancer, and is a rich source of biomarkers for novel diagnostic tests.
Each step is affected by a person's susceptibility, and the continuum provides multiple opportunities for application of biomarkers for early prediction of disease.
3) Studies to validate the utility of biomarkers for use in large population studies (e.
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However, the biomarkers discussed at the meeting are currently under development and none are ready for application.
9 (Translational Biomarkers of Acute Drug Induced Liver Injury: The Current State, Gaps and Future Opportunities (Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta and Shashi Ramaiah)
The report analyst says: "Accurate non-invasive methods for monitoring and quantifying the concentrations of biomarkers are vital for the early diagnosis of disease.
SCOPE AND FORMAT The report analyzes the global biomarker market into the following segments: - Tools Market (pregenomic biomarkers and technologies, postgenomic biomarkers and technologies, imaging biomarkers, and others) - Services Market (pre- and post-clinical biomarker services, sample preparation, mirna analysis, and others) - Application Market (diagnosis, and drug development and discovery)
There is a real desire within our industry for a better understanding of how biomarkers are being incorporated into clinical trials.
Biomarkers in Drug Discovery - Optimizing Drug Discovery Timeline and Cost provides an in-depth analysis on the potential applications of biomarkers in pharmaceutical drug discovery and clinical services.
This Frost & Sullivan research service titled European Biomarker Analysis Market provides revenue forecasts, competitive analysis and market trends for proteomics biomarkers, genomics biomarkers, metabolomic biomarkers, imaging biomarkers, and companion diagnostics.