biomarker


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marker

 [mahr´ker]
something that identifies or that is used to identify; see also determinant.
cell-surface marker an antigenic determinant found on the surface of a specific type of cell.
tumor marker a biochemical substance indicative of presence of a tumor; ideally, it should be specific, sensitive, and proportional to tumor load. Called also biomarker.

biomarker

(bī-ō-mark'ĕr),
A detectable cellular or molecular indicator of exposure, health effects, or susceptibility, which can be used to measure the absorbed, metabolized, or biologically effective dose of a substance, the response to the substance including susceptibility and resistance, idiosyncratic reactions, and other factors or conditions.

biomarker

(bī′ō-mär′kər)
n.
1. Medicine
a. A physiological substance, such as human chorionic gonadotropin or alpha-fetoprotein, that when present in abnormal amounts in the serum may indicate the presence of disease, as that caused by a malignancy.
b. A specific physical trait used to measure or indicate the effects or progress of a disease or condition: Biomarkers of aging include thinning of the hair. Also called biosignature.

biomarker

(1) A characteristic which is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or pharmacologic responses to a therapeutic intervention.
(2) A molecular indicator of a specific biological property or function that can be measured in blood or other body fluids or tissues; a biochemical feature or facet that can be used to suggest the presence of a particular disease, measure its progress or the effects of treatment.
 
Examples
PSA for prostate cancer, Hb1a for glucose control in diabetics, troponin I for acute MI.

biomarker

Diagnostic medicine Any relatively specific biochemical parameter–eg, PSA, Hb1a or troponin I which, when found in ↑ amount in the blood, other body fluids, or tissues, suggest the presence of certain diseases or cancers. See Cardiac marker, Tumor marker.

bi·o·mark·er

(bīō-mahr-kĕr)
A detectable cellular or molecular indicator of exposure,health effects, or susceptibility, which can be used to measure the absorbed, metabolized, or biologically effective dose of a substance, the response to the substance including susceptibility and resistance, idiosyncratic reactions, and other factors or conditions.

Biomarker

A biochemical substance that can be detected in blood samples and indicates the presence of a cancerous tumor.
Mentioned in: Ovarian Cancer

bi·o·mark·er

(bīō-mahr-kĕr)
A detectable cellular or molecular indicator of exposure, health effects, or susceptibility, which can be used to measure the absorbed, metabolized, or biologically effective dose of a substance, the response to the substance including susceptibility and resistance, idiosyncratic reactions, and other factors or conditions.

Patient discussion about biomarker

Q. what is a safe tumor marker number range?

A. depends on the marker...most of the markers are materials that found normally in our body. and there are a number of markers and their levels differentiate. what marker do you mean?

Q. My wife(53) has elevated CEA and CA19.9 levels - near 150, without any concomitant reason/observation? Comment

A. Hi Bobby3,

The most important question is why were these tests done?
An elevated level may result from many causes, some of them are simple and some are more problematic. IMHO the best thing would be consulting her doctor to consider the need to check-up her alimentary system.
You can read more here (http://www.ascocancerfoundation.org/patient/ASCO+Resources/Patient+Guides/ASCO+Patient+Guide:+Tumor+Markers+for+Gastrointestinal+Cancers) and here (http://www.cancer.gov/cancertopics/factsheet/Detection/tumor-markers)

More discussions about biomarker
References in periodicals archive ?
Clinical proteomic biomarkers: relevant issues on study design & technical considerations in biomarker development.
Some of the major players involved in the global biomarkers market include Abbott Laboratories, Medtronic, BG Medicine, Inc., F.
In cancer type segment, breast cancer is expected to account for the largest share of the global cancer biomarkers market.
As has been the case with other novel biomarkers, the combination of two biomarkers--urinary L-FABP and NGAL--enhanced the accuracy of the early detection of postoperative AKI after cardiac surgery well before the associated rise in serum creatinine.
Chapter 6 is the strength of this book with its focus on biomarkers of cancer.
A good biomarker should offer information beyond the usual clinical information.
This type of search for novel biomarkers is somewhat analogous to genomewide association studies.
To identify potential biomarkers, blood samples were collected from 43 subjects with a mean age of 48 years, including 21 with asthma, five with COPD and 17 healthy controls.
Correlation of protein expression and quantitative regulation for diseases of key concern in Japan, such as lung cancer, COPD, and cardiovascular disease, will be performed to discover biomarker candidates related to drug response.
The Web site provides easy access for submitting biomarker project concepts to therapeutic area steering committees within the consortium.
FDA's biomarker qualification guidance will establish a "fitness for use" standard for marker validation, Deputy Commissioner for Operations Janet Woodcock said.
Orion's proprietary biomarker discovery platform, MethylScope(r) technology, was recently published in Nature, and is the subject of numerous patent applications.