biomarker


Also found in: Dictionary, Thesaurus, Legal, Financial, Acronyms, Encyclopedia, Wikipedia.

marker

 [mahr´ker]
something that identifies or that is used to identify; see also determinant.
cell-surface marker an antigenic determinant found on the surface of a specific type of cell.
tumor marker a biochemical substance indicative of presence of a tumor; ideally, it should be specific, sensitive, and proportional to tumor load. Called also biomarker.

biomarker

(bī-ō-mark'ĕr),
A detectable cellular or molecular indicator of exposure, health effects, or susceptibility, which can be used to measure the absorbed, metabolized, or biologically effective dose of a substance, the response to the substance including susceptibility and resistance, idiosyncratic reactions, and other factors or conditions.

biomarker

/bio·mark·er/ (bi´o-mahr″ker)
1. a biological molecule used as a marker for a substance or process of interest.

biomarker

(bī′ō-mär′kər)
n.
1. Medicine
a. A physiological substance, such as human chorionic gonadotropin or alpha-fetoprotein, that when present in abnormal amounts in the serum may indicate the presence of disease, as that caused by a malignancy.
b. A specific physical trait used to measure or indicate the effects or progress of a disease or condition: Biomarkers of aging include thinning of the hair. Also called biosignature.

biomarker

(1) A characteristic which is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or pharmacologic responses to a therapeutic intervention.
(2) A molecular indicator of a specific biological property or function that can be measured in blood or other body fluids or tissues; a biochemical feature or facet that can be used to suggest the presence of a particular disease, measure its progress or the effects of treatment.
 
Examples
PSA for prostate cancer, Hb1a for glucose control in diabetics, troponin I for acute MI.

biomarker

Diagnostic medicine Any relatively specific biochemical parameter–eg, PSA, Hb1a or troponin I which, when found in ↑ amount in the blood, other body fluids, or tissues, suggest the presence of certain diseases or cancers. See Cardiac marker, Tumor marker.

bi·o·mark·er

(bīō-mahr-kĕr)
A detectable cellular or molecular indicator of exposure,health effects, or susceptibility, which can be used to measure the absorbed, metabolized, or biologically effective dose of a substance, the response to the substance including susceptibility and resistance, idiosyncratic reactions, and other factors or conditions.

Biomarker

A biochemical substance that can be detected in blood samples and indicates the presence of a cancerous tumor.
Mentioned in: Ovarian Cancer

bi·o·mark·er

(bīō-mahr-kĕr)
A detectable cellular or molecular indicator of exposure, health effects, or susceptibility, which can be used to measure the absorbed, metabolized, or biologically effective dose of a substance, the response to the substance including susceptibility and resistance, idiosyncratic reactions, and other factors or conditions.

biomarker,

n a short-lived radioactive molecule that can be used as a marker to follow a condition or a process.

biomarker

a biological unit used as an indirect indicator of the impact of pollutants on biota, e.g. an enzyme such as mixed function oxygenase levels, immune status of animals in the receiving environment.

Patient discussion about biomarker

Q. what is a safe tumor marker number range?

A. depends on the marker...most of the markers are materials that found normally in our body. and there are a number of markers and their levels differentiate. what marker do you mean?

Q. My wife(53) has elevated CEA and CA19.9 levels - near 150, without any concomitant reason/observation? Comment

A. Hi Bobby3,

The most important question is why were these tests done?
An elevated level may result from many causes, some of them are simple and some are more problematic. IMHO the best thing would be consulting her doctor to consider the need to check-up her alimentary system.
You can read more here (http://www.ascocancerfoundation.org/patient/ASCO+Resources/Patient+Guides/ASCO+Patient+Guide:+Tumor+Markers+for+Gastrointestinal+Cancers) and here (http://www.cancer.gov/cancertopics/factsheet/Detection/tumor-markers)

More discussions about biomarker
References in periodicals archive ?
In cancer type segment, breast cancer is expected to account for the largest share of the global cancer biomarkers market.
Joint Session: Health Economics Value of Biomarkers & Reimbursement Environment
Sensitivity: The proportion of individuals with confirmed disease who test positive for the biomarker.
Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T.
Chapter 6 is the strength of this book with its focus on biomarkers of cancer.
In fact, good clinical history and examination of patients are of paramount importance in assessing the pre-test probability of an outcome in question, and may dictate whether a nonspecific biomarker is indicated.
The application of biomarkers to risk assessment will require a clear understanding of how environmental exposure indices such as air concentrations and markers of early biologic effects are linked through biomarkers of exposure.
On the basis of regions, the biomarkers market is segmented into Asia-Pacific, Europe, North America, and Latin America and Middle East and Africa.
Physicians and payers across the EU5 see the presence of a biomarker as an advantage, Gheorghe pointed out.
1) Animal or epidemlology studies that explore the relationship between biomarkers of exposure and measures of subclinical disease (early biological effect or altered structure/function).
Biomarker analysis of blood samples from patients with cancer treated with CYC202 demonstrated that 54% (14 of 26 analyzed) tested positive for cancer cell death or apoptosis following single agent treatment with the drug.
6 Biomarkers in Drug Discovery - Technologies Used for Biomarker Discovery