In the initial stage patients will receive escalating doses of SGI-110 until the maximum tolerated dose or the biologically effective dose
They reviewed the literature to determine whether levels of oxidatively damaged DNA and lipid peroxidation products in cells or bodily fluids from humans might be useful biomarkers of biologically effective dose
in studies on the health effects of exposure to PM.
This aflatoxin-DNA adduct excretion product serves as a biomarker of the biologically effective dose
of aflatoxin, and elevated levels are associated with increased risk of liver cancer.
In addition, the younger men were more likely to receive a full biologically effective dose
of radiation: 92% vs.
UV exposure is typically described in terms of a biologically effective dose
rate, in which the radiation flux at each wavelength (E[Lambda]) is multiplied by a weighting factor of the relative biological effect at that wavelength ([Epsilon][Lambda]) (Smith and Baker, 1979).
20] It is not surprising that LDR brachytherapy (which provides a biologically effective dose
of 101 Gy) improves the seven-year biochemical disease-free survival (bDFS) compared to 68 Gy (94% vs.
In the initial stage, patients will receive escalating doses of SGI-110 until the maximum tolerated dose (MTD) or the biologically effective dose
(BED) is determined.
They also proposed four categories of biomarkers: internal dose, biologically effective dose
, early biologic response, and susceptibility.
Patients who received the higher biologically effective dose
(30 Gy) or higher of preoperative radiation had the lower rate of recurrences (Lancet 358:1291-1304, 2001).
These factors can affect the environmental chemical's pharmacokinetics [absorption, distribution, metabolism (biotransformation), and elimination], which can influence the biologically effective dose
, and pharmacodynamics, which can influence the health effects.