biological containment


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biological containment

Any measure used to prevent the replication of recombinant DNA in microorganisms in nature and confine genetically engineered organisms to the lab, by creating biological barriers that prevent their growth outside. Biocontainment strategies include using vectors and host organisms that have been modified to minimise their survival outside of the laboratory.

biological containment

Steps taken to prevent the free replication of laboratory-produced recombinant DNA in the natural environment. A principal method is to use vectors and hosts that have been so modified that they will not survive outside the laboratory.

biological containment


biological containment

methods of protecting the environment from potentially dangerous experimental laboratory organisms. Host ORGANISMS and their VECTORS used in GENETIC ENGINEERING are often developed with special characteristics to enable them to be contained biologically. This may involve the introduction of MUTATIONS that partly disable the organism and vector, thus preventing survival in the natural environment should they escape from the laboratory For example, the host may require certain nutrients that are available in the laboratory but not in the natural environment; it may be sensitive to UV irradiation, or to BILE salts (found in the human GUT); while the vector may be prevented from transferring to other organisms in the environment should it be released. Controllable SUICIDE GENES may be introduced into an organism in such a way that their EXPRESSION can be activated, when the need arises, in order to eliminate the organism.
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Army Medical Research Institute of Infectious Diseases (USAMRIID) would afford the immediate availability of biosafety level 4 laboratories (designed for the study of pathogens requiring maximum biological containment for laboratory safety) and facilitate rapid diagnosis of diseases due to pathogens posing extraordinary laboratory safety hazards.
Maximum biological containment is designed to prevent transmission of highly hazardous pathogens and is accomplished in two steps.
Contract notice: Preventive, corrective, conductive and modifying maintenance of the facilities and systems that serve the level 3 laboratory, biological containment (p3) and other 2 biocontainment laboratories of the national microbiology center, in the campus of the health institute Carlos III .
A Our biological containment laboratories were upgraded last year to BSL3+ enhanced status to support both our work with highly pathogenic organisms, including avian flu, and a contract awarded to the company to develop several testing panels of flu and related organisms for the Centers for Disease Control and Prevention (CDC).
The SIAD process was able to penetrate biological containment filters, totally destroy all Bacillus subtilis spores, and preserve the integrity of the filters.
The ECA wishes to acquire a clinical PET-CT system dedicated to preclinical imaging and the associated system for performing imaging in subjects infected by pathogenic classes 2 and 3, while maintaining the isolation of the camera out biological containment zone.
Its disease scientists, by way of specialized biological containment facilities, provide diagnostic support and research results to public health departments utilizing dead wild birds as sentinels for detecting WNV.