biologic response modifier


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modifier

 [mod´ĭ-fi-er]
1. an agent or method that causes something else to change.
biologic response modifier (BRM) (biological response modifier) a method or agent, such as a cytokine, monoclonal antibody, or vaccine, that alters host-tumor interaction. This is usually accomplished by amplifying the antitumor mechanisms of the immune system, but it also may be effected by mechanisms that affect host or tumor cell characteristics, either directly or indirectly. Called also biomodulator.
problem modifier on level three of the problem classification scheme of the omaha system, either of the two sets of terms used in conjunction with client problems, allowing the nurse to identify ownership of the problem and its degree of severity in relation to client interest, risk factors, and signs or symptoms.

biologic response modifier

agent that modifies host responses to neoplasms by enhancing immune systems or reconstituting impaired immune mechanisms.
Synonym(s): immunomodulator

bi·o·log·ic res·ponse mod·i·fi·er

(bī'ŏ-loj'ik rĕ-spons' mod'i-fī-ĕr)
Agent that modifies host responses to neoplasms by enhancing immune systems or reconstituting impaired immune mechanisms.
References in periodicals archive ?
Use of biologic response modifiers such as interferon-[alpha] was most prevalent in the west north central states stretching from North Dakota and Minnesota south to Kansas and Missouri.
Biologic response modifiers are able to trigger the immune system to indirectly affect tumours by increasing cytokines such as interferons and interleukins.
Drug treatment of the disease includes the use of non-steroidal anti- inflammatory drugs, low dose corticosteroids, disease modifying drugs (DMARDs) such as methotrexate, and most recently biologic response modifiers such as Remicade(R), Enbrel(R), and Kineret(R).
The first in a new class of rheumatoid arthritis (RA) drugs known as biologic response modifiers, ENBREL is an entirely new approach to the management of rheumatoid arthritis.
therapies, such as biologic response modifiers have been shown not only
See FDA briefing document on biologic response modifiers at http://www.
He is a lifelong researcher with interests in new drug development and investigation, as well as biologic response modifiers and the biology of renal cell carcinoma.
Table 2 Biologic Response Modifiers Treatment Recommendations Prior to Total Joint Replacement Surgery Biological Half Life Response Modifiers of Drug * Etanercept 4.
The first in a new class of rheumatoid arthritis drugs known as biologic response modifiers, ENBREL is an entirely novel approach to the management of rheumatoid arthritis.
This briefing is based upon ongoing Healthcare industry analysis and it will benefit pharmaceutical companies that already participate in the segments related to RA, namely COX-2 inhibitors and other non-steroidal drugs (NSAIDs), disease modifying anti-rheumatic drugs (DMARDs) and biologic response modifiers (BRMs) as well as companies intended to enter in those segments in Brazil.