biologic response modifier

Also found in: Dictionary, Thesaurus, Encyclopedia.


1. an agent or method that causes something else to change.
biologic response modifier (BRM) (biological response modifier) a method or agent, such as a cytokine, monoclonal antibody, or vaccine, that alters host-tumor interaction. This is usually accomplished by amplifying the antitumor mechanisms of the immune system, but it also may be effected by mechanisms that affect host or tumor cell characteristics, either directly or indirectly. Called also biomodulator.
problem modifier on level three of the problem classification scheme of the omaha system, either of the two sets of terms used in conjunction with client problems, allowing the nurse to identify ownership of the problem and its degree of severity in relation to client interest, risk factors, and signs or symptoms.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

biologic response modifier

agent that modifies host responses to neoplasms by enhancing immune systems or reconstituting impaired immune mechanisms.
Synonym(s): immunomodulator
Farlex Partner Medical Dictionary © Farlex 2012

bi·o·log·ic res·ponse mod·i·fi·er

(bī'ŏ-loj'ik rĕ-spons' mod'i-fī-ĕr)
Agent that modifies host responses to neoplasms by enhancing immune systems or reconstituting impaired immune mechanisms.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Similarly to biologic response modifiers, Tofacitinib may increase risk for infection and cause liver abnormalities.
More than a third, 38%, were treated with a biologic response modifier: This included 37% of patients with one positive node and 39% of those with two or more positive nodes.
Biologic response modifiers. These are proteins that must be administered by injection.
(1-3) The discovery and development of targeted biologic response modifiers (BRMs), particularly TNF antagonists, for the treatment of RA has dramatically changed the treatment paradigm and clinical outcomes for RA patients.
Top Concerns of Rheumatoid Arthritis Patients Disability 53% Inability to care for self 53% Inability to do hobbies 52% Deformity 45% Inability to care for family 45% Note: Based on a survey of 500 RA patients taking disease-modifying antirheumatic drugs or biologic response modifiers, conducted Aug.
It covers world gynecologic cancer statistics; genes and carcinogenesis; cervical cancer screening; cancer of the vulva, vagina, cervix, endometrium, uterus, fallopian tube, breast, and ovary (including germ cell tumors and sex cord-stromal tumors); gestational trophoblastic diseases; gynecologic cancer during pregnancy; human papillomavirus and vaccination; management of preinvasive disease of the cervix; tumor markers; diagnostic imaging; perioperative care; surgical anatomy and principles; the basic principles of radiotherapy and chemotherapy; modulating agents, biologic response modifiers, and targeted therapy; immunotherapy and hormonal therapy; the management of long-term side effects of treatment; nutrition; basic surgical procedures; and laparoscopic and robotic surgery.
Biologic response modifiers (BRMS) represent a newer subclass of DMARDs and have proven effective in achieving remission, even for patients for whom other therapies have failed.
NIHB does not reimburse for biologic response modifiers needed to combat psoriatic arthritis or ankylosing spondylitis.
Biologic response modifiers, led by Humira and Enbrel, had the greatest impact among specialty drugs.