biochemical failure

biochemical failure

asymptomatic disease recurrence marked only by variance in values determined on clinical laboratory monitoring.

biochemical failure

An oncology term of art referring to an increase in PSA after what was thought to be definitive therapy for prostate cancer, which is usually an indicator of local or metastatic disease progression.
References in periodicals archive ?
Long-term hazard of progression after radical prostatectomy for clinically localized prostate cancer: continued risk of biochemical failure after 5 years.
In the Quebec population-based series of men undergoing LHRH agonist therapy with curative radiation therapy, (24) multivariate analysis adjusting for clinical stage, pretreatment PSA, Gleason score, age, and smoking did not reveal an association between testosterone breakthrough and either biochemical failure or survival; however, subgroup analysis showed a trend toward inferior five-year biochemical failure in those with testosterone breakthroughs of greater than 1.
4 ng/mL after cryosurgery will experience biochemical failure (a rise in PSA levels suggestive of prostate cancer recurrence) within 24 months of the procedure.
31 January 2014 - US genomic tests provider GenomeDx Biosciences announced yesterday new data indicating that its Decipher prostate cancer classifier, which measures the biological risk of metastatic prostate cancer, outperformed existing clinical risk factors for predicting biochemical failure and distant metastasis following radiation therapy
Moreover, it has been shown that biochemical failure is not equal to clinical relapse (2).
James Jensen, Department of Surgery--"Feasibility and Safety of Nutritional Supplementation with Omega-3 Fatty Acids to Reduce Prostate Specific Antigen Rise in Men with Biochemical Failure after Prostatectomy or External-Beam Radiotherapy"
Nor were there differences in biochemical failure, regional or distant recurrence, pelvic metastases, or the need for a second course of androgen blockade.
The researchers then compared the biochemical failure rates (a statistical measure of whether the cancer relapses) and determined that men who received the proton/photon therapy had the same rate of recurrence as the men who received brachytherapy.
Presalvage prostate-specific antigen (PSA) and PSA doubling time as predictors of biochemical failure of salvage cryotherapy in patients with locally recurrent prostate cancer after radiotherapy.
Hypoxic prostate/muscle pO2 (P/M pO2) ratio predicts for biochemical failure in patients with localized prostate cancer: long-term result [abstract 5136].
Many of the high-risk patients that are currently without evidence of biochemical failure had relatively short follow-up in the previous article.