biobreeding rat

biobreeding rat

A proprietary strain of inbred lab rats, which serve as a model for type-1 diabetes, which has been linked to the MHC II gene and Gimap5.
References in periodicals archive ?
Masaoka et al., "The normoglycaemic biobreeding rat: a spontaneous model for impaired gastric accommodation," Gut, vol.
Reichardt, "Type 1 diabetes in biobreeding rats is critically linked to an imbalance between Th17 and regulatory T cells and an altered TCR repertoire," Journal of Immunology, vol.
Gonzalez J, Fevery J (1992) Spontaneously diabetic biobreeding rats and impairment of bile acid independent bile flow and increased biliary bilirubin, calcium and lipid secretion.
To assess NO involvement in the pathophysiology of T1DM, we treated Biobreeding rats, an animal model of autoimmune diabetes, with the general NOS inhibitor LNMMA at early stages of the insulitis process.