bioassay


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bioassay

 [bi″o-as´a]
determination of the active power of a drug sample by comparing its effects on a live animal or an isolated organ preparation with those of a reference standard.

bi·o·as·say

(bī'ō-as'ā),
Determination of the potency or concentration of a compound by its effect on animals, isolated tissues, or microorganisms, as compared with an analysis of its chemical or physical properties.

bioassay

(bī′ō-ăs′ā′, -ă-sā′)
n.
1. Determination of the strength or biological activity of a substance, such as a drug, by comparing its effects with those of a standard preparation on a test organism.
2. A test used to determine such strength or activity.
tr.v. bioas·sayed, bioas·saying, bioas·says
To cause to undergo a bioassay.

bioassay

Lab medicine
Any quantification procedure to detect:
(1) The activity or potency—functional or effective—amount of a substance—e.g., antibiotic, chemical, drug, hormone, metabolit, vitamin, etc.—in a biological fluid;
(2) Toxicity of a substance (e.g., a pollutant) or organism (e.g., a pathogen) of interest in an in vivo system, i.e., in a cell or animal; in bioassays, the effect is tested on living cells or organisms.
 
Molecular biology
An assay that uses a living system, such as an intact cell, to measure an effect or a molecule of interest.
 
Radiation physics
A determination of the quantity of radioactive material in the human body, either by direct measurement—in vivo counting—or by analysis of excreta.

bi·o·as·say

(bī'ō-as'ā)
Determination of the potency or concentration of a compound by its effect on animals, isolated tissues, or microorganisms, as contrasted with analysis of its chemical or physical properties.
Synonym(s): biologic assay, biotest.

bioassay

A method of measuring the potency of a drug or other biochemical agent by comparing its effects on animals with those of known preparations of standard strength.
References in periodicals archive ?
To identify potential toxicity mechanisms and further optimize the initial bioprofile, the 1,077 PubChem bioassays were clustered based on shared chemical fragments relevant to bioassay responses.
As the sample was positive in the neuro-2a bioassay (Bodero et al., 2018a) and resulted in a clear profile in the multiplex magnetic bead-based assay, this sample might also contain an unknown AZA or YTX analogue.
Therefore, this bioassay could provide basic information on the effect of different insecticide formulations and entomopathogenic fungi on adult mosquitoes.
We recently reported on novel cell-based cannabinoid (CB) reporter bioassays for the detection of SCs and their metabolites, demonstrating cannabinoid activity in authentic urine samples (7, 8).
For the [LC.sub.50] bioassays, a total of 600 first-instar larvae of P vetula were field-collected at the same site but were maintained at 25 [+ or -] 1[degrees]C up to the third instar.
The authors are indebted to the financial support provided by the HEC (Higher Education Commission, Pakistan) and HEJ-RIC, University of Karachi for providing necessary space and facilities for bioassays.
* What other technologies can be brought in as a future bioassay platform?
The smaller number of viable eggs in the bioassay by contact, compared to the bioassay by immersion, is probably related to the protective effect of the chorion layers, which act as a barrier to foreign substances.
The efficacies of 6 types of LLINs distributed as part of the National Malaria Control Program of Burkina Faso were assessed against the Kisumu and VK7 mosquito strains to assess the effect of resistance on LLIN effectiveness in a standardized WHO bioassay. New nets and nets that had been in use in the field for [approximately equal to] 2 years were assessed.
In bioassay 2, the results indicate physiological selectivity of the extract of A.