The role of specific nutrients or bioactive food components
on breast cancer risk still remains obscure.
The response to a bioactive food component
may be very subtle; therefore, characterization and quantification of small cellular changes are very important.
The initial impact of nutrigenomics on dietetics will be felt increasingly over the next decade and then will escalate as the research foundation clarifies the interactions among genes, environment and bioactive food components
and provides the basis for using these food components to effect desirable outcomes.
Classes of chemopreventive agents: anti-inflammatory agents, modulators of cancer-associated pathways, modulators of epidermal growth factor receptor signaling pathways, modulators of TGF-beta/Smad signaling pathway, modulators of nuclear-receptor superfamily, bioactive food components
He says: "Overall, we are trying to understand the cellular and molecular mechanisms underlying the development of fat cells in the body, especially by bioactive food components
, with the goal to find therapeutic strategies for not only preventing chronic diseases such as obesity, cancer and heart disease, but promoting overall health.
In addition, the report calls for expanded research on traditional nutrients, other bioactive food components
and the intersection of genomics and molecular nutrition.
In addition, clinical trials of therapies for cancer treatment, including but not limited to herbal therapies, dietary supplements, bioactive food components
, or unconventional pharmacological and biological interventions (e.
Using the example of the omega-3 fatty acid EPA, Dr Halperin from Harvard argued that bioactive food components
can show how gene action can occur at a number of levels and thus how food may have an impact on a number of diseases.
In addition to nutrients found in sweet cherries, there are a wide variety of bioactive food components
that have been associated with improved health.
1: Assessing the Health Effects of Bioactive Food Components
, Bethesda, MD: National Institutes of Health, contact: Leila Saldanha, 301-435-2920; Fax: 301-480-1845; E-mail: saldanhl@mail.