However, certain components in these media such as bile salts
and phospholipids raised suspicions regarding the possible toxic effects on cell lines (Ingels and Augustijns 2003; Birch et al.
We know that any dietary factor that reduces the availability of taurine precursors, binds taurine bile salts
in the intestine, or causes an increase in the bacteria populations that degrade taurine can reduce a dog's ability to synthesize taurine or will increase taurine degradation and/or loss in the feces.
Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt
The main criterion for selecting a probiotic strain is the assessment of its pH and bile tolerance since the first biological barriers to be overcome after ingestion to reach its place of action are the acid in the stomach and bile salts
in the intestine (Fuller, 1989).
In the present study, we used the methodology by Tanaka, Hashiba, Kok, and Mierau (2000) based on the deconjugation of TDCA (sodium tauro deoxycholate hydrate--Sigma Aldrich) and GDCA (Glyco deoxy cholic acid monohydrate Sigma Aldrich) bile salts
per Lactobacillus acidophilus strains.
Faber et al., "Farnesoid X receptor and bile salts
are involved in transcriptional regulation of the gene encoding the human bile salt
export pump," Hepatology, vol.
The results suggested that most of the LAB strains used in the study are tolerant to bile salt
at low concentration (Figure 1).
hydrolase activity and resistance to toxicity of conjugated bile salts
are unrelated properties in Lactobacilli.
Renal involvement in malaria varies widely from mild-to-moderate proteinuria with accompanying urinary sediments containing RBCs and granular and/ or hyaline cast and bile salts
and bile pigments if associated with hepatic involvement.
The toxic effects of elevated intracellular bile salts
and bilirubin lead to portal and systemic endotoxemia, fluid-electrolyte imbalances, and malnutrition (2).
Further, KCC-32 displayed potential probiotic characteristics including resistant to low pH, bile salt
tolerance, auto-aggregation and hydrophobicity.
In view of the regulatory abilities of PDZK1 and the regulation of CBS on BCRP and MRP2, we speculated that PDZK1 might participate in CBS-regulated bile salt
delivering and play an important role in restoring biliary transport function in EE-induced intrahepatic cholestasis.